uu.seUppsala University Publications
Change search
ReferencesLink to record
Permanent link

Direct link
Influence of two blood conservation techniques (cardiotomy reservoir versus cell-saver) on biocompatibility of the heparin coated cardiopulmonary bypass circuit during coronary revascularization surgery
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Surgical Sciences. (Thoracic Surgery)
Show others and affiliations
1997 (English)In: Journal of cardiac surgery, ISSN 0886-0440, E-ISSN 1540-8191, Vol. 12, no 3, 190-197 p.Article in journal (Refereed) Published
Abstract [en]

Blood conservation during cardiac surgery is critically important because of the inherent risks in homologous blood transfusions. Two techniques for the intraoperative conservation of blood--retransfusion of the red cells using a cell-saver (CS), or retransfusion of the blood using a cardiotomy suction (CTR) system--were compared using biocompatibility markers, granulocyte activation, and production of oxygen-free radicals (OFR). In the CTR group, heparin coated circuits with an uncoated cardiotomy reservoir were used. For the CS group, identical heparin coated cardiopulmonary bypass (CPB) sets, without a cardiotomy reservoir but with a CS, were used. In each group, eight patients had coronary artery bypass grafting performed. The capacity of the whole blood and the granulocytes to produce OFR was estimated by a chemiluminescence, and granulocyte activation was measured as release of the granulocyte granule proteins myeloperoxidase (MPO) and lactoferrin. A significantly reduced capacity to produce OFR by the whole blood was noted at 45 minutes of CPB in the CTR group (68% +/- 17% vs 94% +/- 16% in the CS group). MPO release was higher after 3 hours (p = 0.05) and 20 hours (p < 0.05), postoperatively, in the CTR group (417 +/- 77 micrograms/L and 257 +/- 31 micrograms/L vs 246 +/- 25 micrograms/L and 164 +/- 12 micrograms/L, respectively, in the CS group). We conclude that the heparin coated CPB circuit with the uncoated cardiotomy reservoir may be less biocompatible than the identical CPB set used together with the CS.

Place, publisher, year, edition, pages
1997. Vol. 12, no 3, 190-197 p.
National Category
Medical and Health Sciences
URN: urn:nbn:se:uu:diva-55703DOI: 10.1111/j.1540-8191.1997.tb00122.xPubMedID: 9395949OAI: oai:DiVA.org:uu-55703DiVA: diva2:83611
Available from: 2008-10-17 Created: 2008-10-17 Last updated: 2011-01-13Bibliographically approved

Open Access in DiVA

No full text

Other links

Publisher's full textPubMed

Search in DiVA

By author/editor
Venge, Per
By organisation
Department of Surgical SciencesDepartment of Medical Sciences
In the same journal
Journal of cardiac surgery
Medical and Health Sciences

Search outside of DiVA

GoogleGoogle Scholar

Altmetric score

Total: 173 hits
ReferencesLink to record
Permanent link

Direct link