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Bone response to a novel Ti-Ta-Nb-Zr alloy
Uppsala University, Disciplinary Domain of Science and Technology, Technology, Department of Engineering Sciences, Applied Materials Sciences.
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2015 (English)In: Acta Biomaterialia, ISSN 1742-7061, E-ISSN 1878-7568, Vol. 20, 165-175 p.Article in journal (Refereed) Published
Abstract [en]

Commercially pure titanium (cp-Ti) is regarded as the state-of-the-art material for bone-anchored dental devices, whereas the mechanically stronger alloy (Ti-6Al-4V), made of titanium, aluminum (Al) and vanadium (V), is regarded as the material of choice for high-load applications. There is a call for the development of new alloys, not only to eliminate the potential toxic effect of Al and V but also to meet the challenges imposed on dental and maxillofacial reconstructive devices, for example. The present work evaluates a novel, dual-stage, acid-etched, Ti-Ta-Nb-Zr alloy implant, consisting of elements that create low toxicity, with the potential to promote osseointegration in vivo. The alloy implants (denoted Ti-Ta-Nb-Zr) were evaluated after 7 days and 28 days in a rat tibia model, with reference to commercially pure titanium grade 4 (denoted Ti). Analyses were performed with respect to removal torque, histomorphometry and gene expression. The Ti-Ta-Nb-Zr showed a significant increase in implant stability over time in contrast to the Ti. Further, the histological and gene expression analyses suggested faster healing around the Ti-Ta-Nb-Zr, as judged by the enhanced remodeling, and mineralization, of the early-formed woven bone and the multiple positive correlations between genes denoting inflammation, bone formation and remodeling. Based on the present experiments, it is concluded that the Ti-Ta-Nb-Zr alloy becomes osseointegrated to at least a similar degree to that of pure titanium implants. This alloy is therefore emerging as a novel implant material for clinical evaluation.

Place, publisher, year, edition, pages
2015. Vol. 20, 165-175 p.
Keyword [en]
Osseointegration, Removal torque, Gene expression, Titanium alloy, Tantalum (Ta)
National Category
Biomaterials Science Engineering and Technology
Research subject
Engineering Science with specialization in Materials Science
URN: urn:nbn:se:uu:diva-256981DOI: 10.1016/j.actbio.2015.03.038ISI: 000355708200018PubMedID: 25848727OAI: oai:DiVA.org:uu-256981DiVA: diva2:838719
Available from: 2015-07-01 Created: 2015-06-29 Last updated: 2016-04-22Bibliographically approved

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Brohede, UlrikaNorgren, Susanne
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