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Kainic acid, tetrodotoxin and light modulate expression of brain-derived neurotrophic factor in developing avian retinal ganglion cells and their tectal target
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Neuroscience, Developmental Neuroscience. (FH)
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Neuroscience, Developmental Neuroscience.
1998 (English)In: Neuroscience, ISSN 0306-4522, E-ISSN 1873-7544, Vol. 83, no 1, 137-150 p.Article in journal (Refereed) Published
Abstract [en]

Increasing evidence underlies the importance of neurotrophins as neuron-derived trophic signals in the developing visual system, although their precise roles are still undefined. Here we show that brain-derived neurotrophic factor messenger RNA is simultaneously expressed in a subpopulation of retinal ganglion cells and in their target during late embryogenesis. Moreover, light as well as the excitotoxin; kainic acid, induced an increase of the brain-derived neurotrophic factor messenger RNA, which could be blocked by the sodium-channel blocker; tetrodotoxin. Messenger RNA for trkB, a receptor for brain-derived neurotrophic factor, was found in the retinal ganglion cells expressing brain-derived neurotrophic factor showing that certain retinal ganglion cells express messenger RNA both for brain-derived neurotrophic factor and trkB. Furthermore, trkB messenger RNA was found in tectum, in the same layers as the brain-derived neurotrophic factor messenger RNA. These findings suggest that brain-derived neurotrophic factor expression is regulated in an activity-dependent manner during the phase of development when neuronal activity plays an important role.

Place, publisher, year, edition, pages
1998. Vol. 83, no 1, 137-150 p.
National Category
Neurosciences
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URN: urn:nbn:se:uu:diva-55997DOI: 10.1016/S0306-4522(97)00340-0PubMedID: 9466404OAI: oai:DiVA.org:uu-55997DiVA: diva2:83905
Available from: 2008-10-17 Created: 2008-10-17 Last updated: 2017-12-04Bibliographically approved

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Hallböök, Finn

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