Kainic acid, tetrodotoxin and light modulate expression of brain-derived neurotrophic factor in developing avian retinal ganglion cells and their tectal target
1998 (English)In: Neuroscience, ISSN 0306-4522, E-ISSN 1873-7544, Vol. 83, no 1, 137-150 p.Article in journal (Refereed) Published
Increasing evidence underlies the importance of neurotrophins as neuron-derived trophic signals in the developing visual system, although their precise roles are still undefined. Here we show that brain-derived neurotrophic factor messenger RNA is simultaneously expressed in a subpopulation of retinal ganglion cells and in their target during late embryogenesis. Moreover, light as well as the excitotoxin; kainic acid, induced an increase of the brain-derived neurotrophic factor messenger RNA, which could be blocked by the sodium-channel blocker; tetrodotoxin. Messenger RNA for trkB, a receptor for brain-derived neurotrophic factor, was found in the retinal ganglion cells expressing brain-derived neurotrophic factor showing that certain retinal ganglion cells express messenger RNA both for brain-derived neurotrophic factor and trkB. Furthermore, trkB messenger RNA was found in tectum, in the same layers as the brain-derived neurotrophic factor messenger RNA. These findings suggest that brain-derived neurotrophic factor expression is regulated in an activity-dependent manner during the phase of development when neuronal activity plays an important role.
Place, publisher, year, edition, pages
1998. Vol. 83, no 1, 137-150 p.
IdentifiersURN: urn:nbn:se:uu:diva-55997DOI: 10.1016/S0306-4522(97)00340-0PubMedID: 9466404OAI: oai:DiVA.org:uu-55997DiVA: diva2:83905