The Granule Porosity Controls the Loss of Compactibility for Both Dry- and Wet-Processed Cellulose Granules but at Different Rate
2015 (English)In: Journal of Pharmaceutical Sciences, ISSN 0022-3549, E-ISSN 1520-6017, Vol. 104, no 6, 2029-2039 p.Article in journal (Refereed) Published
The aim of this study was to investigate the role of porosity on the compression behavior and tablet tensile strength for granules produced by a dry granulation procedure. Microcrystalline cellulose was used as a typical pharmaceutical excipient and a comparison was made with the effect of granule porosity on the compression behavior and tablet tensile strength of wet-processed granules of the same composition. Both the wet and dry granulation process caused a loss in compactibility of the material that was controlled by the granule porosity up to a critical point of porosity and friability. Above this threshold value of porosity, the granules nearly collapsed completely into primary particles during compression. In these cases, the micro-structure and tensile strength of the formed tablets resembled that of tablets formed from the original ungranulated powder.
Place, publisher, year, edition, pages
2015. Vol. 104, no 6, 2029-2039 p.
compaction, compression, granulation, granules, cellulose, porosity, powder technology, tablets, tableting, tensile strength
Pharmacology and Toxicology
IdentifiersURN: urn:nbn:se:uu:diva-256220DOI: 10.1002/jps.24439ISI: 000354458800016PubMedID: 25872760OAI: oai:DiVA.org:uu-256220DiVA: diva2:839944