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Second malignancies following treatment of chronic myeloid leukaemia in the tyrosine kinase inhibitor era
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Haematology.
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2015 (English)In: British Journal of Haematology, ISSN 0007-1048, E-ISSN 1365-2141, Vol. 169, no 5, 683-688 p.Article in journal (Refereed) Published
Abstract [en]

Given that tyrosine kinase inhibitors (TKIs) have dramatically improved the survival of patients with chronic myeloid leukaemia (CML), we were interested in examining the possible risk of long-term adverse events, such as the emergence of other neoplasms. Therefore, we studied the development of second malignancies in 868 patients diagnosed with CML between 2002 and 2011 using the Swedish CML register, cross-linked to the Swedish Cancer register. With a median follow-up of 37 (range 0-99)years, 65 (75%) patients developed 75 second malignancies (non-haematological), 52 of which were of the invasive type. Compared to expected rates in the background population, the risk of second malignancies was higher in the CML cohort, with a standardized incidence ratio (SIR) of 152 (95% CI 113-199). The SIR before and after the second year following diagnosis of CML was 158 and 147, respectively. Among specific cancer types, gastrointestinal and nose and throat cancer were significantly increased. Founded on a population-based material, our results indicate that CML patients treated in the TKI era are at an increased risk of developing a second malignancy, with indications that this risk may more likely be linked to CML itself rather than to the TKI treatment.

Place, publisher, year, edition, pages
2015. Vol. 169, no 5, 683-688 p.
Keyword [en]
chronic myeloid leukaemia, treatment, malignancy
National Category
Hematology
Identifiers
URN: urn:nbn:se:uu:diva-256211DOI: 10.1111/bjh.13346ISI: 000354489800009PubMedID: 25817799OAI: oai:DiVA.org:uu-256211DiVA: diva2:840015
Available from: 2015-07-06 Created: 2015-06-22 Last updated: 2017-12-04Bibliographically approved

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Höglund, MartinOlsson-Strömberg, Ulla

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