uu.seUppsala University Publications
Change search
ReferencesLink to record
Permanent link

Direct link
The patient perspective: Quality of life in advanced heart failure with frequent hospitalisations
Show others and affiliations
2015 (English)In: International Journal of Cardiology, ISSN 0167-5273, E-ISSN 1874-1754, Vol. 191, 256-264 p.Article, review/survey (Refereed) Published
Abstract [en]

End of life is an unfortunate but inevitable phase of the heart failure patients' journey. It is often preceded by a stage in the progression of heart failure defined as advanced heart failure, and characterised by poor quality of life and frequent hospitalisations. In clinical practice, the efficacy of treatments for advanced heart failure is often assessed by parameters such as clinical status, haemodynamics, neurohormonal status, and echo/MRI indices. From the patients' perspective, however, quality-of-life-related parameters, such as functional capacity, exercise performance, psychological status, and frequency of re-hospitalisations, are more significant. The effects of therapies and interventions on these parameters are, however, underrepresented in clinical trials targeted to assess advanced heart failure treatment efficacy, and data are overall scarce. This is possibly due to a non-universal definition of the quality-of-life-related endpoints, and to the difficult standardisation of the data collection. These uncertainties also lead to difficulties in handling trade-off decisions between quality of life and survival by patients, families and healthcare providers. A panel of 34 experts in the field of cardiology and intensive cardiac care from 21 countries around the world convened for reviewing the existing data on quality-of-life in patients with advanced heart failure, discussing and reaching a consensus on the validity and significance of quality-of-life assessment methods. Gaps in routine care and research, which should be addressed, were identified. Finally, published data on the effects of current i.v. vasoactive therapies such as inotropes, inodilators, and vasodilators on quality-of-life in advanced heart failure patients were analysed.

Place, publisher, year, edition, pages
2015. Vol. 191, 256-264 p.
Keyword [en]
Advanced heart failure, Quality of life, Trade-off, Levosimendan, Nitroprusside, Nesiritide
National Category
Cardiac and Cardiovascular Systems
URN: urn:nbn:se:uu:diva-258566DOI: 10.1016/j.ijcard.2015.04.235ISI: 000356053500068OAI: oai:DiVA.org:uu-258566DiVA: diva2:842065
Available from: 2015-07-16 Created: 2015-07-15 Last updated: 2015-07-16Bibliographically approved

Open Access in DiVA

fulltext(508 kB)77 downloads
File information
File name FULLTEXT01.pdfFile size 508 kBChecksum SHA-512
Type fulltextMimetype application/pdf

Other links

Publisher's full text

Search in DiVA

By author/editor
Wikström, Gerhard
By organisation
In the same journal
International Journal of Cardiology
Cardiac and Cardiovascular Systems

Search outside of DiVA

GoogleGoogle Scholar
Total: 77 downloads
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

Altmetric score

Total: 216 hits
ReferencesLink to record
Permanent link

Direct link