uu.seUppsala University Publications
Change search
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf
Treatment with serotonin reuptake inhibitors during pregnancy is associated with elevated corticotropin-releasing hormone levels
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Women's and Children's Health, Obstetrics and Gynaecology.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Women's and Children's Health, Obstetrics and Gynaecology.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Women's and Children's Health, Obstetrics and Gynaecology.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Women's and Children's Health, Obstetrics and Gynaecology.
Show others and affiliations
2015 (English)In: Psychoneuroendocrinology, ISSN 0306-4530, E-ISSN 1873-3360, Vol. 58, 104-113 p.Article in journal (Refereed) Published
Abstract [en]

Treatment with serotonin reuptake inhibitors (SSRI) has been associated with an increased risk of preterm birth, but causality remains unclear. While placental CRH production is correlated with gestational length and preterm birth, it has been difficult to establish if psychological stress or mental health problems are associated with increased CRH levels. This study compared second trimester CRH serum concentrations in pregnant women on SSRI treatment (n=207) with untreated depressed women (n=56) and controls (n=609). A secondary aim was to investigate the combined effect of SSRI treatment and CRH levels on gestational length and risk for preterm birth. Women on SSRI treatment had significantly higher second trimester CRH levels than controls, and untreated depressed women. CRH levels and SSRI treatment were independently associated with shorter gestational length. The combined effect of SSRI treatment and high CRH levels yielded the highest risk estimate for preterm birth. SSRI treatment during pregnancy is associated with increased CRH levels. However, the elevated risk for preterm birth in SSRI users appear not to be mediated by increased placental CRH production, instead CRH appear as an independent risk factor for shorter gestational length and preterm birth.

Place, publisher, year, edition, pages
2015. Vol. 58, 104-113 p.
Keyword [en]
Corticotropin releasing hormone, Depression, Pregnancy, Serotohin reuptake inhibitor, Gestational length, Preterm birth
National Category
Neurosciences
Identifiers
URN: urn:nbn:se:uu:diva-258740DOI: 10.1016/j.psyneuen.2015.04.009ISI: 000356738700010PubMedID: 25978816OAI: oai:DiVA.org:uu-258740DiVA: diva2:842569
Funder
Swedish Research Council, K2014-54X-20642-07-4Marianne and Marcus Wallenberg Foundation, 2010:0031
Available from: 2015-07-21 Created: 2015-07-20 Last updated: 2017-12-04Bibliographically approved

Open Access in DiVA

No full text

Other links

Publisher's full textPubMed

Authority records BETA

Hannerfors, Anna-KarinHellgren, CharlotteIliadis, Stavros I.Comasco, ErikaSkalkidou, AlkistisOlivier, Jocelien D. A.Sundström-Poromaa, Inger

Search in DiVA

By author/editor
Hannerfors, Anna-KarinHellgren, CharlotteIliadis, Stavros I.Comasco, ErikaSkalkidou, AlkistisOlivier, Jocelien D. A.Sundström-Poromaa, Inger
By organisation
Obstetrics and GynaecologyNeuro-psycho-pharmacology
In the same journal
Psychoneuroendocrinology
Neurosciences

Search outside of DiVA

GoogleGoogle Scholar

doi
pubmed
urn-nbn

Altmetric score

doi
pubmed
urn-nbn
Total: 679 hits
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf