Translational Aspects of Blood-Brain Barrier Transport and Central Nervous System Effects of Drugs: From Discovery to Patients
2015 (English)In: Clinical Pharmacology and Therapeutics, ISSN 0009-9236, E-ISSN 1532-6535, Vol. 97, no 4, 380-394 p.Article in journal (Refereed) Published
The development of CNS drugs is associated with high failure rates. It is postulated that too much focus has been put on BBB permeability and too little on understanding BBB transport, which is the main limiting factor in drug delivery to the brain. An integrated approach to collecting, understanding, and handling pharmacokinetic-pharmacodynamic information from early discovery stages to the clinic is therefore recommended in order to improve translation to human drug treatment.
Place, publisher, year, edition, pages
2015. Vol. 97, no 4, 380-394 p.
Research subject Pharmacokinetics and Drug Therapy
IdentifiersURN: urn:nbn:se:uu:diva-258820DOI: 10.1002/cpt.76ISI: 000351432700024PubMedID: 25670219OAI: oai:DiVA.org:uu-258820DiVA: diva2:842934