uu.seUppsala University Publications
Change search
ReferencesLink to record
Permanent link

Direct link
Translational Aspects of Blood-Brain Barrier Transport and Central Nervous System Effects of Drugs: From Discovery to Patients
Leiden University, the Netherlands.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Pharmacy, Department of Pharmaceutical Biosciences. Uppsala University. (Translational PKPD)
2015 (English)In: Clinical Pharmacology and Therapeutics, ISSN 0009-9236, E-ISSN 1532-6535, Vol. 97, no 4, 380-394 p.Article in journal (Refereed) Published
Abstract [en]

The development of CNS drugs is associated with high failure rates. It is postulated that too much focus has been put on BBB permeability and too little on understanding BBB transport, which is the main limiting factor in drug delivery to the brain. An integrated approach to collecting, understanding, and handling pharmacokinetic-pharmacodynamic information from early discovery stages to the clinic is therefore recommended in order to improve translation to human drug treatment.

Place, publisher, year, edition, pages
2015. Vol. 97, no 4, 380-394 p.
National Category
Pharmaceutical Sciences
Research subject
Pharmacokinetics and Drug Therapy
URN: urn:nbn:se:uu:diva-258820DOI: 10.1002/cpt.76ISI: 000351432700024PubMedID: 25670219OAI: oai:DiVA.org:uu-258820DiVA: diva2:842934
Available from: 2015-07-23 Created: 2015-07-20 Last updated: 2016-05-11Bibliographically approved

Open Access in DiVA

No full text

Other links

Publisher's full textPubMed

Search in DiVA

By author/editor
Hammarlund-Udenaes, Margareta
By organisation
Department of Pharmaceutical Biosciences
In the same journal
Clinical Pharmacology and Therapeutics
Pharmaceutical Sciences

Search outside of DiVA

GoogleGoogle Scholar
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

Altmetric score

Total: 323 hits
ReferencesLink to record
Permanent link

Direct link