Spatio-Temporal Control of Growth Factor Binding and Release in Bisphosphonate Functionalized Hydrogels Guides Rapid Differentiation of Precursor Cells in vitro
(English)In: Journal of materials chemistry. B, ISSN 2050-750X, E-ISSN 2050-7518Article in journal (Refereed) Submitted
An in situ cross-linkable hyaluronan hydrogel functionalized with bisphosphonate (BP) groups allows tunable release of bone morphogenetic protein-2 (BMP-2) determined by the amount of BP groups. Sequestration of BMP-2 in the hydrogel permits guided differentiation of entrapped progenitor cells in 3-D cultures.
Place, publisher, year, edition, pages
Royal Society of Chemistry.
bisphosphonates, hydrogels, growth factors, tissue engineering, biomaterials
Research subject Chemistry with specialization in Polymer Chemistry; Chemistry with specialization in Materials Chemistry
IdentifiersURN: urn:nbn:se:uu:diva-259081OAI: oai:DiVA.org:uu-259081DiVA: diva2:843140
FunderEU, European Research Council, 262948-2EU, FP7, Seventh Framework Programme, 238551