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Anabolic steroids and cardiovascular risk: A national population-based cohort study
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Surgical Sciences, Forensic Medicine.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Medicinska och farmaceutiska vetenskapsområdet, centrumbildningar mm, UCR-Uppsala Clinical Research Center.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Surgical Sciences, Endocrine Surgery.
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2015 (English)In: Drug And Alcohol Dependence, ISSN 0376-8716, E-ISSN 1879-0046, Vol. 152, 87-92 p.Article in journal (Refereed) Published
Abstract [en]

Background: Non-therapeutic use of anabolic androgenic steroids (AAS) has been associated with various adverse effects; one of the most serious being direct cardiovascular effects with unknown long-term consequences. Therefore, large studies of the association between AAS and cardiovascular outcomes are warranted. We investigated cardiovascular morbidity and mortality in individuals who tested positive for AAS. Methods and results: Between 2002 and 2009, a total of 2013 men were enrolled in a cohort on the date of their first AAS test. Mortality and morbidity after cohort entry was retrieved from national registries. Of the 2013 individuals, 409(20%) tested positive for MS. These men had twice the cardiovascular morbidity and mortality rate as those with negative tests (adjusted hazard ratio (aHR) 2.0; 95% confidence interval (CI) 1.2-3.3). Compared to the Swedish population, all tested men had an increased risk of premature death from all causes (standardized mortality ratio for MS-positive: 19.3, 95% CI 12.4-30.0; for AAS-negative: 8.3,95% CI 6.1-11.0). Conclusion: Non-therapeutic exposure to MS appears to be an independent risk factor for cardiovascular morbidity and premature death.

Place, publisher, year, edition, pages
2015. Vol. 152, 87-92 p.
Keyword [en]
Anabolic androgenic steroids, Mortality, Morbidity, Cardiac disease, Psychiatric disease, Injury
National Category
Substance Abuse Psychiatry
Identifiers
URN: urn:nbn:se:uu:diva-259103DOI: 10.1016/j.drugalcdep.2015.04.013ISI: 000356738300012PubMedID: 26005042OAI: oai:DiVA.org:uu-259103DiVA: diva2:843453
Available from: 2015-07-28 Created: 2015-07-27 Last updated: 2017-12-04

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Thiblin, IngemarGarmo, HansHolmberg, LarsByberg, LiisaMichaëlsson, KarlGedeborg, Rolf

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