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The body mass index (BMI) is significantly correlated with levels of cytokines and chemokines in cerebrospinal fluid
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Biochemial structure and function.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Biochemial structure and function.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Surgical Sciences, Anaesthesiology and Intensive Care.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Surgical Sciences, Anaesthesiology and Intensive Care.
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2015 (English)In: Cytokine, ISSN 1043-4666, E-ISSN 1096-0023, Vol. 76, no 2, 514-518 p.Article in journal (Refereed) Published
Abstract [en]

Cytokines and chemokines regulate many functions in the body including the brain. The interactions between adipose tissue and the central nervous system (CNS) are important for the regulation of energy balance. CNS function is also influenced by age. The aim of the present study was to investigate the effects of body mass index (BMI) and age on cytokine and chemokine levels in cerebrospinal fluid. Cerebrospinal fluid samples (n=89) were collected from patients undergoing routine surgical procedures. The samples were analyzed using the multiplex proximity extension assay (PEA) in which 92 different cytokines are measured simultaneously using minute sample volume. We found no significant correlations between age and cytokine levels for any of the studied markers. In contrast, at a false discovery rate of 10%, 19 markers were significantly associated with BMI (in decreasing significance: FGF-5, ADA, Beta-NGF, CD40, IL-10RB, CCL19, TGF-alpha, SIRT2, TWEAK, SCF, CSF-1, 4E-BP1, DNER, LIF-R, STAMPB, CXCL10, CXCL6, VEGF-A and CX3CL1). This study reveals a clear effect of BMI on cytokine and chemokine levels in cerebrospinal fluid.

Place, publisher, year, edition, pages
2015. Vol. 76, no 2, 514-518 p.
Keyword [en]
Age; Body mass index; Cytokine; Human; Proximity extension assay (PEA); Cerebrospinal fluid
National Category
Clinical Laboratory Medicine
Identifiers
URN: urn:nbn:se:uu:diva-259347DOI: 10.1016/j.cyto.2015.07.010ISI: 000364244400051PubMedID: 26188367OAI: oai:DiVA.org:uu-259347DiVA: diva2:843860
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VINNOVASwedish Research Council
Available from: 2015-07-31 Created: 2015-07-31 Last updated: 2017-12-04Bibliographically approved

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Larsson, AndersCarlsson, LenaLind, Anne-LiGordh, TorstenKamali-Moghaddam, MasoodThulin, Måns

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Larsson, AndersCarlsson, LenaLind, Anne-LiGordh, TorstenKamali-Moghaddam, MasoodThulin, Måns
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Biochemial structure and functionAnaesthesiology and Intensive CareDepartment of Immunology, Genetics and PathologyScience for Life Laboratory, SciLifeLabDepartment of Statistics
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