Can Cobalt(II) and Chromium(III) Ions Released from Joint Prostheses Influence the Friction Coefficient?
2015 (English)In: ACS Biomaterials Science & Engineering, Vol. 1, no 8, 617-620 p.Article in journal (Refereed) Published
Cobalt chromium molybdenum alloys (CoCr-Mo) are commonly used as articulating components in joint prostheses. In this tribocorrosive environment, wear debris and metal ionic species are released and interact with proteins, possibly resulting in protein aggregation. This study aimed to investigate whether this could have an eff ect on the friction coefficient in a typical material couple, namely CoCrMo-onpolyethylene. It was confirmed that both Co(II) and Cr(III) ions, and their combination, at concentrations relevant for the metal release situation, resulted in protein aggregation and its concomitant precipitation, which increased the friction coeffi cient. Future studies should identify the clinical importance of these findings.
Place, publisher, year, edition, pages
2015. Vol. 1, no 8, 617-620 p.
hip joint, replacement, friction, protein-metal binding, CoCrMo, alloy tribology
Other Materials Engineering Medical Materials
Research subject Engineering Science with specialization in Materials Science
IdentifiersURN: urn:nbn:se:uu:diva-259426DOI: 10.1021/acsbiomaterials.5b00183ISI: 000372214100001OAI: oai:DiVA.org:uu-259426DiVA: diva2:844097
FunderEU, FP7, Seventh Framework Programme, GA-310477Swedish Research Council, 2013-5621