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Synergistic inhibitory effects of interferon-alpha and 5-fluorouracil on human meningeoma cells in vitro
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Neuroscience, Neurology.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Neuroscience, Neurology.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Neuroscience, Neurology.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Neuroscience, Neurology.
1996 (English)In: Cancer Letters, ISSN 0304-3835, E-ISSN 1872-7980, Vol. 100, no 1-2, 99-105 p.Article in journal (Refereed) Published
Abstract [en]

We have investigated the effects of interferon-α (IFN-α) and 5-fluorouracil (5-FU) on meningioma cells in two different culture systems, evaluated by the uptake of radiolabelled methionine. With both IFN-α and 5-FU an inhibitory effect on the uptake of radiolabelled methionine by the meningioma cells was demonstrated, and we found a synergistic inhibitory effect with a combination of IFN-α and 5-FU. To obtain a maximal inhibition of cell metabolism without causing cell toxicity, we were able to decrease the dose of 5-FU by simultaneously adding IFN-α. Our results suggest that a combined treatment of IFN-α and 5-FU may be a successful alternative for patients with inoperable meningiomas. A novel in vitro positron emission tomography technique was used for the study of metabolic changes in tumour cells caused by drug treatment, which is complementary to conventional cell culture techniques.

Place, publisher, year, edition, pages
1996. Vol. 100, no 1-2, 99-105 p.
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Medical and Health Sciences
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URN: urn:nbn:se:uu:diva-56572DOI: 10.1016/0304-3835(95)04076-5PubMedID: 8620460OAI: oai:DiVA.org:uu-56572DiVA: diva2:84480
Available from: 2008-10-17 Created: 2008-10-17 Last updated: 2017-12-04Bibliographically approved

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Muhr, CarinSmits, Anja

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