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Novel polyglycidol-lipid conjugates create a stabilizing hydrogen-bonded layer around cholesterol-containing dipalmitoyl phosphatidylcholine liposomes
Institute of Polymers, Bulgarian Academy of Sciences, 103-A Acad. G. Bonchev St., 1113 Sofia, Bulgaria.
Department of Pharmaceutical Technology and Biopharmaceutics, Faculty of Pharmacy, Medical University e Sofia, 2 Dunav St., 1000 Sofia, Bulgaria.
Uppsala University, Disciplinary Domain of Science and Technology, Chemistry, Department of Chemistry - BMC, Analytical Chemistry.
Department of Pharmacology, Pharmacotherapy and Toxicology, Faculty of Pharmacy, Medical University e Sofia, 2 Dunav St., 1000 Sofia, Bulgaria.
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2015 (English)In: Journal of Drug Delivery Science and Technology, ISSN 1773-2247, Vol. 29, 90-98 p.Article in journal (Refereed) Published
Abstract [en]

Hybrid liposomes resulting from co-assembly of dipalmitoylphosphatidylcholine and polyglycidol-derivatized lipids were prepared. The latter were composed of a lipid-mimetic residue to which a linear polyglycidol chain (degree of polymerization, DP, in the 23–110 range) was conjugated. Formulations with varying copolymer type and content were prepared by film hydration technique followed by extrusion. The hybrid structures were studied by means of dynamic and electrophoretic light scattering, cryogenic transmission electron microscopy, and fluorescence spectroscopy. Cytotoxicity towards OPM-2 (multiple myeloma) and EJ (human urinary bladder carcinoma) cell lines was assessed as well. Predominantly unilamellar liposomes with mean hydrodynamic diameters in the 113–134 nm range and neutral to slightly negative surface potential were prepared. The integrity of liposomes containing copolymers with DP of the polyglycidol chain 23 and 30 was preserved at copolymer contents up to 10 mol%. Bilayer disks were observed at somewhat lower contents of the copolymers of the highest DP of the polyglycidol chain. The hybrid structures were less leaky than the plain liposomes, which was attributed to formation of a strongly hydrogen-bonded polyglycidol layer around the bilayer membrane. They exhibited low toxicological potential, favorable physicochemical characteristics, and ability to act as containers for sustained release.

Place, publisher, year, edition, pages
Elsevier, 2015. Vol. 29, 90-98 p.
Keyword [en]
Polymer grafted liposomes, Polyglycidol, Hydrogen bonds, Cytotoxicity
National Category
Chemical Sciences Pharmaceutical Sciences
URN: urn:nbn:se:uu:diva-259682DOI: 10.1016/j.jddst.2015.06.019ISI: 000362608900011OAI: oai:DiVA.org:uu-259682DiVA: diva2:845063
EU, European Research Council, 316086Swedish Research Council, 621-2011-3524Swedish Cancer Society, CAN20111504
Available from: 2015-08-10 Created: 2015-08-10 Last updated: 2015-11-16Bibliographically approved

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Publisher's full texthttp://www.sciencedirect.com/science/article/pii/S1773224715001148

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