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Hippocampal hemispheric and long-axis differentiation of stimulus content during episodic memory encoding and retrieval: An activation likelihood estimation meta-analysis
Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Social Sciences, Department of Psychology. Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Neuroscience, Psychiatry, University Hospital.
Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Social Sciences, Department of Psychology.
2015 (English)In: Hippocampus, ISSN 1050-9631, E-ISSN 1098-1063, Vol. 25, no 12, 1614-1631 p.Article in journal (Refereed) Published
Abstract [en]

While there is ample evidence that the hippocampus is functionally heterogeneous along its longitudinal axis, there is still no consensus regarding its exact organization. Whereas spatial memory tasks frequently engage the posterior hippocampus, the regions engaged during episodic memory are more varying and may depend on the specific nature of the stimuli. Here, we investigate the effect of stimulus content on the location of hippocampal recruitment during episodic memory encoding and retrieval of pictorial and verbal material with a meta-analysis approach, using activation likelihood estimation and restricting the analysis to the hippocampus. Verbal material was associated with left-lateralized anterior activation, compared to pictorial material that recruited a more posterior aspect of the hippocampus, primarily within the right hemisphere. This effect held for encoding of both single items and item-item associations but was less clear during retrieval. The findings lend further support to a functional subdivision of the hippocampus along its longitudinal axis and indicate that the content of episodic memories is one factor that determines the location of hippocampal recruitment.

Place, publisher, year, edition, pages
2015. Vol. 25, no 12, 1614-1631 p.
Keyword [en]
meta-analysis; hippocampus; episodic memory; spatial memory; activation likelihood estimation; encoding; retrieval
National Category
Psychology
Identifiers
URN: urn:nbn:se:uu:diva-259778DOI: 10.1002/hipo.22482ISI: 000368281700012PubMedID: 26108671OAI: oai:DiVA.org:uu-259778DiVA: diva2:845422
Available from: 2015-08-11 Created: 2015-08-11 Last updated: 2017-12-04Bibliographically approved
In thesis
1. Making Head or Tail of the Hippocampus: A Long-Axis Account of Episodic and Spatial Memory
Open this publication in new window or tab >>Making Head or Tail of the Hippocampus: A Long-Axis Account of Episodic and Spatial Memory
2015 (English)Doctoral thesis, comprehensive summary (Other academic)
Abstract [en]

While episodic and spatial memory both depend on the hippocampus, opposite gender differences in these functions suggest they are partly separate, with different neural underpinnings. The anterior and posterior hippocampus differ  in structure and whole-brain connectivity, and studies point to the posterior hippocampus being more involved in spatial memory while the anterior hippocampus’ role in episodic memory is less clear. This thesis aims to explore the role of the anterior and posterior hippocampus, and associated brain regions, in episodic and spatial memory. Paper I studied gender differences in hippocampal activation underlying differences in spatial memory performance. Better performance in men was accompanied by greater right-lateralization of hippocampal activation compared to women. Paper II investigated regions of gray matter that covaried in volume with the anterior and posterior hippocampus, and whether these covariance patterns depended on gender and were related to behavior. The anterior and posterior hippocampus showed different patterns of covariance, with the anterior hippocampus covariance pattern observed in women and the posterior hippocampus covariance pattern primarily in men. Paper III considered whether the location of hippocampal recruitment in episodic memory depends on memory content. Verbal stimuli were associated with more anterior, and left-lateralized, encoding activations than pictorial stimuli, which in turn were associated with more posterior and bilateral encoding activations. This was not observed during retrieval. Paper IV investigated whether resting-state connectivity associated with the anterior and posterior hippocampus predicts episodic and spatial memory performance, respectively. Resting-state connectivity associated with the anterior, not posterior, hippocampus predicted episodic memory performance, while resting-state connectivity associated with the posterior, not anterior, hippocampus predicted spatial memory performance. This thesis lends further support to differences in function and structure between the anterior and posterior hippocampus suggesting that these two sub–segments play different roles in episodic and spatial memory. Further, it suggests that gender differences in anterior and posterior hippocampus function underlies gender differences in episodic and spatial memory, respectively. Considering the anterior and posterior hippocampus, as well as men and women, separately, is hence important when studying the effect of age and pathology on the hippocampus and associated memory functions.

Place, publisher, year, edition, pages
Uppsala: Acta Universitatis Upsaliensis, 2015. 81 p.
Series
Digital Comprehensive Summaries of Uppsala Dissertations from the Faculty of Social Sciences, ISSN 1652-9030 ; 114
Keyword
hippocampus, fMRI, episodic memory, spatial memory, gender differences
National Category
Psychology (excluding Applied Psychology) Neurosciences
Research subject
Psychology
Identifiers
urn:nbn:se:uu:diva-261340 (URN)978-91-554-9328-8 (ISBN)
Public defence
2015-10-23, Auditorium Minus, Gustavianum, Akademigatan 3, Uppsala, 10:15 (English)
Opponent
Supervisors
Available from: 2015-09-28 Created: 2015-09-01 Last updated: 2015-10-01

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Persson, JonasSöderlund, Hedvig

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