uu.seUppsala University Publications
Change search
ReferencesLink to record
Permanent link

Direct link
Comparison of Tetrahydroisoquinoline (TIQ) Thiazole and Oxazoline Ligands for Asymmetric Henry Reactions
Uppsala University, Disciplinary Domain of Science and Technology, Chemistry, Department of Chemistry - BMC.
Show others and affiliations
2012 (English)In: South African Journal of Chemistry, ISSN 0379-4350, Vol. 65, 23-29 p.Article in journal (Refereed) Published
Abstract [en]

A series of novel C-1 symmetric thiazole ligands with a tetrahydroisoquinoline (TIQ) backbone were synthesized. Their application in the catalytic asymmetric Henry reaction was investigated with comparison to a corresponding TIQ oxazoline ligand. The Cu(II)-oxazoline complex was more reactive and furnished moderate enantioselectivities up to 61:36 (syn:anti) with 75:25 diastereomeric excess, while the Cu(II)-thiazole complexes had lower selectivity. This is the first example where a direct comparison between an N, N-type thiazole and oxazoline ligands has been studied.

Place, publisher, year, edition, pages
2012. Vol. 65, 23-29 p.
Keyword [en]
Tetrahydroisoquinoline, thiazole, oxazoline, Henry reaction, enantioselectivity
National Category
Chemical Sciences
URN: urn:nbn:se:uu:diva-259779ISI: 000301284200005OAI: oai:DiVA.org:uu-259779DiVA: diva2:845423
Available from: 2015-08-11 Created: 2015-08-11 Last updated: 2015-08-11Bibliographically approved

Open Access in DiVA

No full text

By organisation
Department of Chemistry - BMC
In the same journal
South African Journal of Chemistry
Chemical Sciences

Search outside of DiVA

GoogleGoogle Scholar
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

Total: 175 hits
ReferencesLink to record
Permanent link

Direct link