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Glial Cell Responses, Complement and Clusterin in the Central Nervous System Following Dorsal Root Transection
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Neuroscience, Neuroanatomy.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Neuroscience, Neuroanatomy.
1998 (English)In: Glia, ISSN 0894-1491, E-ISSN 1098-1136, Vol. 23, no 3, 221-238 p.Article in journal (Refereed) Published
Abstract [en]

We have examined the glial cell response, the possible expression of compounds associated with the complement cascade, including the putative complement inhibitor clusterin, and their cellular association during Wallerian degeneration in the central nervous system. Examination of the proliferation pattern revealed an overall greater mitotic activity after rhizotomy, an exclusive involvement of microglia in this proliferation after peripheral nerve injury, but, in addition, a small fraction of proliferating astrocytes after rhizotomy. Immunostaining with the phagocytic cell marker ED1 gradually became very prominent after rhizotomy, possibly reflecting a response to the extensive nerve fiber disintegration. Lumbar dorsal rhizotomy did not induce endogenous immunoglobulin G (IgG) deposition or complement expression in the spinal cord dorsal horn, dorsal funiculus, or gracile nucleus. This is in marked contrast to the situation after peripheral nerve injury, which appears to activate the entire complement cascade in the vicinity of the central sensory processes. Clusterin, a multifunctional protein with complement inhibitory effects, was markedly upregulated in the dorsal funiculus in astrocytes. In addition, there was an intense induction of clusterin expression in the degenerating white matter in oligodendrocytes, possibly reflecting a degeneration process in these cells. The findings suggest that 1) complement expression by microglial cells is intimately associated with IgG deposition; 2) axotomized neuronal perikarya, but not degenerating central fibers, undergo changes which induce such deposition; and 3) clusterin is not related to complement expression following neuronal injury but participates in regulating the state of oligodendrocytes during Wallerian degeneration.

Place, publisher, year, edition, pages
1998. Vol. 23, no 3, 221-238 p.
National Category
Medical and Health Sciences
Research subject
URN: urn:nbn:se:uu:diva-56719DOI: 10.1002/(SICI)1098-1136(199807)23:3<221::AID-GLIA5>3.0.CO;2-7PubMedID: 9633807OAI: oai:DiVA.org:uu-56719DiVA: diva2:84628
Available from: 2008-10-17 Created: 2008-10-17 Last updated: 2011-11-16Bibliographically approved

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