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The cerebrospinal fluid biomarker profile in an HIV-infected subject with Alzheimer's disease
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Public Health and Caring Sciences, Geriatrics.
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2015 (English)In: AIDS research and therapy, ISSN 1742-6405, E-ISSN 1742-6405, Vol. 12, 23Article in journal (Refereed) Published
Abstract [en]

It is a challenge to differentiate between HIV-associated neurocognitive disorders (HAND) and other types of neurocognitive disease in the ageing HIV-infected population. Here we describe a 63 year old HIV-infected woman who had a history, neuropsychological test result, and PET examination consistent with characteristic Alzheimer's disease (AD). The cerebrospinal fluid (CSF) biomarker profile was analogous to the profile typically found in AD in HIV-negative patients with increased t-tau and p-tau, a decreased level of A beta 42 and normal levels of CSF neurofilament light protein and sAPP alpha and sAPP beta, distinctly different from findings in HIV-associated dementia (HAD). Assessment of CSF biomarkers may be a valuable tool for clinicians to distinguish between HAD and AD.

Place, publisher, year, edition, pages
2015. Vol. 12, 23
Keyword [en]
Alzheimer's disease, HIV, CSF biomarkers
National Category
Infectious Medicine
Identifiers
URN: urn:nbn:se:uu:diva-259645DOI: 10.1186/s12981-015-0063-xISI: 000357784300001PubMedID: 26175795OAI: oai:DiVA.org:uu-259645DiVA: diva2:847613
Funder
Swedish Research Council
Note

Swedish Research Council K2011-58P-20931-01-4 K2010-63P-21562-01-4  K2011-61X-20401-05-6 2013-2546 K2013-61X-14002-13-5; Sahlgrenska University Hospital ALF-GBG 430271 ALFGBG 441051 ALFGBG 139671 

Available from: 2015-08-20 Created: 2015-08-10 Last updated: 2017-12-04Bibliographically approved

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Kilander, Lena

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