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Is excessive daytime sleepiness a separate manifestation in Parkinson's disease?
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Neuroscience, Psychiatry, University Hospital.
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2015 (English)In: Acta Neurologica Scandinavica, ISSN 0001-6314, E-ISSN 1600-0404, Vol. 132, no 2, 97-104 p.Article in journal (Refereed) Published
Abstract [en]

BackgroundExcessive daytime sleepiness (EDS) is common in Parkinson's disease (PD), but its role and relation to other PD features is less well understood. ObjectiveTo investigate potential predictors of EDS in PD and to explore how EDS relates to other motor and non-motor PD features. Methods118 consecutive persons with PD (54% men; mean age, 64) were assessed regarding EDS using the Epworth Sleepiness Scale (ESS) and a range of motor and non-motor symptoms. Variables significantly associated with ESS scores in bivariate analyses were used in multiple regression analyses with ESS scores as the dependent variable. Principal component analysis (PCA) was conducted to explore the interrelationships between ESS scores and other motor and non-motor PD aspects. ResultsAmong 114 persons with complete ESS data, significant independent associations were found between ESS scores and axial/postural/gait impairment, depressive symptoms, and pain (R-2, 0.199). ESS scores did not load significantly together with any other PD features in the PCA. ConclusionsOnly a limited proportion of the variation in EDS could be accounted for by other symptoms, and EDS did not cluster together with any other PD features in PCAs. This suggests that EDS is a separate manifestation differing from, for example, poor sleep quality and fatigue.

Place, publisher, year, edition, pages
2015. Vol. 132, no 2, 97-104 p.
Keyword [en]
disorders of excessive somnolence, factor analysis, Parkinson's disease, symptom assessment, regression analysis
National Category
Neurology
Identifiers
URN: urn:nbn:se:uu:diva-259633DOI: 10.1111/ane.12378ISI: 000357735300004PubMedID: 25630925OAI: oai:DiVA.org:uu-259633DiVA: diva2:847754
Funder
Swedish Research Council
Note

Funding: Swedish Parkinson Foundation, Swedish Parkinson Academy, Basal Ganglia Disorders Linnaeus Consortium (BAGADILICO) at Lund University, Department of Neurology, Karolinska University Hospital Huddinge, Stockholm, Sweden 

Available from: 2015-08-21 Created: 2015-08-10 Last updated: 2017-12-04Bibliographically approved

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Broman, Jan-Erik

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