The influence of Sr content in calcium phosphate coatings
2015 (English)In: Materials science & engineering. C, biomimetic materials, sensors and systems, ISSN 0928-4931, E-ISSN 1873-0191, Vol. 53, 322-330 p.Article in journal (Refereed) Published
In this study calcium phosphate coatings with different amounts of strontium.(Sr) were prepared using a biomineralization method. The incorporation of Sr changed the composition and morphology of coatings from plate-like to sphere-like morphology. Dissolution testing indicated that the solubility of the coatings increased with increased Sr concentration. Evaluation of extracts (with Sr concentrations ranging from 0 to 237 mu g/mL) from the HA, 0.06Sr, 0.6Sr, and 12Sr coatings during in vitro cell cultures showed that Sr incorporation into coatings significantly enhanced the ALP activity in comparison to cells treated with control and HA eluted media. These findings show that calcium phosphate coatings could promote osteogenic differentiation even in a low amount of strontium. (C) 2015 Elsevier B.V. All rights reserved.
Place, publisher, year, edition, pages
2015. Vol. 53, 322-330 p.
Strontium, Calcium phosphate coatings, Ion release, In vitro study
IdentifiersURN: urn:nbn:se:uu:diva-260277DOI: 10.1016/j.msec.2015.04.015ISI: 000358093600039PubMedID: 26042720OAI: oai:DiVA.org:uu-260277DiVA: diva2:847809
FunderSwedish Research Council, 2013-5419