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Effect of Acrylamide on Liver and Kidneys in Albino Wistar Rats
(University of Sulaimania)
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Respiratory Medicine and Allergology. University of Sulaimania.
(University of Sulaimania)
2015 (English)In: Int.J.Curr.Microbiol.App.Sci, ISSN 2319-7706, Vol. 4, no 5, 434-444 p.Article in journal (Refereed) Published
Place, publisher, year, edition, pages
Int.J.Curr.Microbiol.App.Sci, 2015. Vol. 4, no 5, 434-444 p.
Keyword [en]
Acrylamide, Hepatocyte, Inflammation, Remodeling, Wistar rats
National Category
Other Medical Sciences not elsewhere specified
Research subject
Animal Development
URN: urn:nbn:se:uu:diva-260675OAI: oai:DiVA.org:uu-260675DiVA: diva2:847963

Acrylamide (ACR) is a chemical with a very wide range of uses and it accounts for oneof the major health concern because it has been detected in a widely consumed fooditem, fried breads (or any carbohydrate-rich food items cooked at high temperature)accordingly the general population is highly exposed to ACR. Four groups of adultfemale rats were used in this study to investigate the effects of different doses of ACRadministration on the liver and kidneys. Group1: Control was given distilled water;group 2: low dose given 2mg /kg/day; group 3: mild dose given 10mg/kg/day andgroup 4: high dose given 30mg/kg/day ACR, the doses were given orally for eightweeks. Results showed no significant differences in serum urea and creatinine level ofthe low dose group, while mild and higher dose groups showed significant decreasescompared with control. No significant differences recorded in T.S. bilirubin levels inall treated groups. S. uric acid levels significantly increased in the low dose group, butits level significantly decreased in both mild and high dose groups compared to thecontrol. Levels of each of S. total protein, S. albumin, S. globulin, S.G.P.T., S.G.O.T.and S.A.L.P was significantly decreased in all treated groups compared with control.Histological examinations of the liver and kidneys of the all groups treated with ACRrevealed degeneration of the glomerular tuft, the epithelial lining of the kidney's brushborder membrane and liver hepatocyte. Both liver and kidneys showed congestion inthe blood vessels. For the first time, three different doses of acrylamide have beeninvestigated, and tested for both physiological and histopatholgical changes. It has beenconcluded that body can tolerate and detoxificat low ACR doses. While mild and highdoses lead to degenerative changes and physiopathological disturbance, indicate thelocal action of ACR on both the liver and kidney cells and remodeling as they are themain sites of detoxification and excretion of toxic materials of administeringsubstances. A significant decrease in body weight in Wistar rat treated with variousconcentrations of ACR in comparison to control groups. This is probably the result ofbreakdown of tissue and blood cells in the liver and kidney by ACR in Wistar rats.

Available from: 2015-08-21 Created: 2015-08-21 Last updated: 2015-10-20Bibliographically approved

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Amin, Kawa A. M.
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