uu.seUppsala University Publications
Change search
ReferencesLink to record
Permanent link

Direct link
A prezygotic transmission distorter acting equally in female and male zebra finches Taeniopygia guttata
Uppsala University, Disciplinary Domain of Science and Technology, Biology, Department of Ecology and Genetics, Evolutionary Biology.
Show others and affiliations
2015 (English)In: Molecular Ecology, ISSN 0962-1083, E-ISSN 1365-294X, Vol. 24, no 15, 3846-3859 p.Article in journal (Refereed) Published
Abstract [en]

The two parental alleles at a specific locus are usually inherited with equal probability to the offspring. However, at least three processes can lead to an apparent departure from fair segregation: early viability selection, biased gene conversion and various kinds of segregation distortion. Here, we conduct a genome-wide scan for transmission distortion in a captive population of zebra finches (Taeniopygia guttata) using 1302 single-nucleotide polymorphisms (SNPs) followed by confirmatory analyses on independent samples from the same population. In the initial genome-wide scan, we found significant distortion at three linked loci on chromosome Tgu2 and we were able to replicate this finding in each of two follow-up data sets [overall transmission ratio=0.567 (95% CI=0.536-0.600), based on 1101 informative meioses]. Although the driving allele was preferentially transmitted by both heterozygous females [ratio=0.560 (95% CI=0.519-0.603)] and heterozygous males [ratio=0.575 (95% CI=0.531-0.623)], we could rule out postzygotic viability selection and biased gene conversion as possible mechanisms. Early postzygotic viability selection is unlikely, because it would result in eggs with no visible embryo and hence no opportunity for genotyping, and we confirmed that both females and males heterozygous for the driving allele did not produce a larger proportion of such eggs than homozygous birds. Biased gene conversion is expected to be rather localized, while we could trace transmission distortion in haplotypes of several megabases in a recombination desert. Thus, we here report the rare case of a prezygotically active transmission distorter operating equally effectively in female and male meioses.

Place, publisher, year, edition, pages
2015. Vol. 24, no 15, 3846-3859 p.
Keyword [en]
genic drive, meiotic drive, segregation distortion, selfish DNA
National Category
Evolutionary Biology Ecology Biochemistry and Molecular Biology
URN: urn:nbn:se:uu:diva-260613DOI: 10.1111/mec.13281ISI: 000358335300006PubMedID: 26087713OAI: oai:DiVA.org:uu-260613DiVA: diva2:848220
Swedish Research CouncilKnut and Alice Wallenberg FoundationMax Planck SocietyGerman Research Foundation (DFG), SCHI 1188/1-1, FO340/1-1, FO340/1-2, FO340/1-3EU, FP7, Seventh Framework Programme, HPMF-CT-2002-01871
Available from: 2015-08-24 Created: 2015-08-21 Last updated: 2015-08-24Bibliographically approved

Open Access in DiVA

No full text

Other links

Publisher's full textPubMed

Search in DiVA

By author/editor
Ellegren, Hans
By organisation
Evolutionary Biology
In the same journal
Molecular Ecology
Evolutionary BiologyEcologyBiochemistry and Molecular Biology

Search outside of DiVA

GoogleGoogle Scholar
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

Altmetric score

Total: 235 hits
ReferencesLink to record
Permanent link

Direct link