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Evolutionary consequences of drug resistance: shared principles across diverse targets and organisms
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Biochemistry and Microbiology.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Biochemistry and Microbiology.
2015 (English)In: Nature reviews genetics, ISSN 1471-0056, E-ISSN 1471-0064, Vol. 16, no 8, 459-471 p.Article, review/survey (Refereed) Published
Abstract [en]

Drug therapy has a crucial role in the treatment of viral, bacterial, fungal and protozoan infections, as well as the control of human cancer. The success of therapy is being threatened by the increasing prevalence of resistance. We examine and compare mechanisms of drug resistance in these diverse biological systems (using HIV and Plasmodium falciparum as examples of viral and protozoan pathogens, respectively) and discuss how factors-such as mutation rates, fitness effects of resistance, epistasis and clonal interference-influence the evolutionary trajectories of drug-resistant clones. We describe commonalities and differences related to resistance development that could guide strategies to improve therapeutic effectiveness and the development of a new generation of drugs.

Place, publisher, year, edition, pages
2015. Vol. 16, no 8, 459-471 p.
National Category
Microbiology in the medical area
Identifiers
URN: urn:nbn:se:uu:diva-261056DOI: 10.1038/nrg3922ISI: 000358075900008PubMedID: 26149714OAI: oai:DiVA.org:uu-261056DiVA: diva2:849567
Funder
EU, FP7, Seventh Framework ProgrammeSwedish Research CouncilKnut and Alice Wallenberg Foundation
Available from: 2015-08-28 Created: 2015-08-28 Last updated: 2017-12-04Bibliographically approved

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Hughes, DiarmaidAndersson, Dan I.

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