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Non-melanoma skin cancer may be a marker of poor prognosis in patients with non-Hodgkin's lymphoma
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Oncology, Radiology and Clinical Immunology.
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2000 (English)In: International Journal of Cancer, ISSN 0020-7136, E-ISSN 1097-0215, Vol. 85, no 5, 639-642 p.Article in journal (Refereed) Published
Abstract [en]

According to recent results, patients with non-melanoma skin cancers are at increased risk of developing non-Hodgkin's lymphoma (NHL). The prognostic significance of this association is unknown. Two cohorts of patients with a first diagnosis of non-melanoma skin cancer and a subsequent diagnosis of either NHL (n = 170) or colon cancer (n = 435) were established using national cancer registry data in Denmark. Two other cohorts of patients in whom NHL (n = 600) or colon cancer (n = 1,541) was the patients' first known malignancy served as comparison groups. Mortality rates were compared using Cox's regression analysis. Among patients younger than 80 years at NHL diagnosis, a history of non-melanoma skin cancer was associated with significantly increased mortality [relative risk (RR) = 1.54; 95% confidence interval: 1.19-1.99]. This association was present in both men (RR = 1.38; 1.02-1.86) and women (RR = 2.15; 1.31-3.54) and was similar after both major subtypes of non-melanoma skin cancer. Overall, antedating non-melanoma skin cancer had no prognostic significance for colon cancer patients (RR = 1.00; 0.84-1.18). Whatever the underlying mechanism, our observation has potential clinical implications. If substantiated in other settings, NHL patients with prior non-melanoma skin cancer may constitute a subgroup of lymphoma patients in need of particular therapeutic attention.

Place, publisher, year, edition, pages
2000. Vol. 85, no 5, 639-642 p.
National Category
Medical and Health Sciences
URN: urn:nbn:se:uu:diva-57164DOI: 10.1002/(SICI)1097-0215(20000301)85:5<639::AID-IJC7>3.0.CO;2-LPubMedID: 10699942OAI: oai:DiVA.org:uu-57164DiVA: diva2:85073
Available from: 2008-10-17 Created: 2008-10-17 Last updated: 2010-11-22Bibliographically approved

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