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Inhibition of Ebola virus glycoprotein-mediated cytotoxicity by targeting its transmembrane domain and cholesterol
Uppsala University, Science for Life Laboratory, SciLifeLab. Uppsala University, Disciplinary Domain of Science and Technology, Biology, Department of Cell and Molecular Biology, Molecular Evolution.
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2015 (English)In: Nature Communications, ISSN 2041-1723, E-ISSN 2041-1723, Vol. 6, 7688Article in journal (Refereed) Published
Abstract [en]

The high pathogenicity of the Ebola virus reflects multiple concurrent processes on infection. Among other important determinants, Ebola fusogenic glycoprotein (GP) has been associated with the detachment of infected cells and eventually leads to vascular leakage and haemorrhagic fever. Here we report that the membrane-anchored GP is sufficient to induce the detachment of adherent cells. The results show that the detachment induced through either full-length GP(1,2) or the subunit GP(2) depends on cholesterol and the structure of the transmembrane domain. These data reveal a novel molecular mechanism in which GP regulates Ebola virus assembly and suggest that cholesterol-reducing agents could be useful as therapeutics to counteract GP-mediated cell detachment.

Place, publisher, year, edition, pages
2015. Vol. 6, 7688
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Biochemistry and Molecular Biology
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URN: urn:nbn:se:uu:diva-261317DOI: 10.1038/ncomms8688ISI: 000358858100032PubMedID: 26158910OAI: oai:DiVA.org:uu-261317DiVA: diva2:851007
Available from: 2015-09-03 Created: 2015-09-01 Last updated: 2017-12-04Bibliographically approved

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Bjorkholm, Patrik

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