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Vascular permeability - the essentials
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Immunology, Genetics and Pathology, Vascular Biology.
2015 (English)In: Upsala Journal of Medical Sciences, ISSN 0300-9734, E-ISSN 2000-1967, Vol. 120, no 3, 135-143 p.Article, review/survey (Refereed) Published
Abstract [en]

The vasculature, composed of vessels of different morphology and function, distributes blood to all tissues and maintains physiological tissue homeostasis. In pathologies, the vasculature is often affected by, and engaged in, the disease process. This may result in excessive formation of new, unstable, and hyperpermeable vessels with poor blood flow, which further promotes hypoxia and disease propagation. Chronic vessel permeability may also facilitate metastatic spread of cancer. Thus, there is a strong incentive to learn more about an important aspect of vessel biology in health and disease: the regulation of vessel permeability. The current review aims to summarize current insights into different mechanisms of vascular permeability, its regulatory factors, and the consequences for disease.

Place, publisher, year, edition, pages
2015. Vol. 120, no 3, 135-143 p.
Keyword [en]
Edema, histamine, junctions, pore, vascular permeability, VEGF
National Category
Cancer and Oncology
URN: urn:nbn:se:uu:diva-262144DOI: 10.3109/03009734.2015.1064501ISI: 000359819800001PubMedID: 26220421OAI: oai:DiVA.org:uu-262144DiVA: diva2:852476
Swedish Cancer Society, CAN2013/661Swedish Research Council, 2010-2521Knut and Alice Wallenberg Foundation
Available from: 2015-09-09 Created: 2015-09-09 Last updated: 2015-09-09Bibliographically approved

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