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The Specific Requirements for CR1 Retrotransposition Explain the Scarcity of Retrogenes in Birds
Uppsala University, Disciplinary Domain of Science and Technology, Biology, Department of Ecology and Genetics, Evolutionary Biology.
2015 (English)In: Journal of Molecular Evolution, ISSN 0022-2844, E-ISSN 1432-1432, Vol. 81, no 1-2, 18-20 p.Article in journal, Letter (Refereed) Published
Abstract [en]

Chicken repeat 1 (CR1) retroposons are the most abundant superfamily of transposable elements in the genomes of birds, crocodilians, and turtles. However, CR1 mobilization remains poorly understood. In this article, I document that the diverse CR1 lineages of land vertebrates share a highly conserved hairpin structure and an octamer microsatellite motif at their very 3' ends. Together with the presence of these same motifs in the tails of CR1-mobilized short interspersed elements, this suggests that the minimum requirement for CR1 transcript recognition and retrotransposition is a complex > 50-nt structure. Such a highly specific recognition sequence readily explains why CR1-dominated genomes generally contain very few retrogenes. Conversely, the mammalian richness in retrogenes results from CR1 extinction in their early evolution and subsequent establishment of L1 dominance.

Place, publisher, year, edition, pages
2015. Vol. 81, no 1-2, 18-20 p.
Keyword [en]
Chicken repeat 1, Long interspersed element, Retrotransposition, Microsatellite, Retrogene, Land vertebrates
National Category
Evolutionary Biology
URN: urn:nbn:se:uu:diva-262139DOI: 10.1007/s00239-015-9692-xISI: 000359823600003PubMedID: 26223967OAI: oai:DiVA.org:uu-262139DiVA: diva2:852500
Available from: 2015-09-09 Created: 2015-09-09 Last updated: 2015-09-09Bibliographically approved

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