uu.seUppsala University Publications
Change search
ReferencesLink to record
Permanent link

Direct link
Pregnancy and risk of non-Hodgkin´s lymphoma: a prospective study
Show others and affiliations
1997 (English)In: International Journal of Cancer, ISSN 0020-7136, Vol. 70, no 2, 155-158 p.Article in journal (Refereed) Published
Abstract [en]

The etiology of non-Hodgkin's lymphomas (NHL), including chronic lymphocytic leukemia (CLL), is likely to be related to immune function. In the light of the established immunologic effects of a pregnancy, we decided to examine the risk of NHL and CLL in relationship to full-term pregnancies. Within a nationwide cohort we identified 1,546 women with NHL and 198 women with CLL, all 15 years or older, born 1925-1972. Five age-matched controls were selected for each case patient. Conditional logistic regression was used to estimate the odds ratios after mutual adjustment for number of births and age at first birth. We found a weak, negative association between parity and risk of NHL (p for trend 0.11) and a transient, 10-40% decrease in risk within 5-14 years after the last birth among women with various parity status. The risk of CLL decreased more markedly, and orderly with increasing parity, but the trend was not significant (p = 0.18). Small numbers of cases with CLL prevented more detailed analyses of temporal relationships. Age at first birth appeared unrelated to the risk of both NHL and CLL. We conclude that the immunologic alterations associated with a pregnancy have limited, if any, relevance to the etiology of NHL and CLL; changing reproductive pattern is an unlikely contributor to the marked increase in incidence of NHL seen in many populations.

Place, publisher, year, edition, pages
1997. Vol. 70, no 2, 155-158 p.
National Category
Medical and Health Sciences
URN: urn:nbn:se:uu:diva-57412DOI: 10.1002/(SICI)1097-0215(19970117)70:2<155::AID-IJC3>3.0.CO;2-WPubMedID: 9009153OAI: oai:DiVA.org:uu-57412DiVA: diva2:85321
Available from: 2008-10-17 Created: 2008-10-17 Last updated: 2009-10-29Bibliographically approved

Open Access in DiVA

No full text

Other links

Publisher's full textPubMed
By organisation
Department of Oncology, Radiology and Clinical Immunology
In the same journal
International Journal of Cancer
Medical and Health Sciences

Search outside of DiVA

GoogleGoogle Scholar
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

Altmetric score

Total: 178 hits
ReferencesLink to record
Permanent link

Direct link