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Spatio-Temporal Control of Growth Factor Binding and Release in Bisphosphonate Functionalized Hydrogels Guides Rapid Differentiation of Precursor Cells in vitro
Uppsala University, Disciplinary Domain of Science and Technology, Chemistry, Department of Chemistry - Ångström, Polymer Chemistry. Uppsala University, Science for Life Laboratory, SciLifeLab. (Jöns Hilborn/Biomaterials)
Uppsala University, Disciplinary Domain of Science and Technology, Chemistry, Department of Chemistry - Ångström, Polymer Chemistry. Uppsala University, Science for Life Laboratory, SciLifeLab.
Uppsala University, Disciplinary Domain of Science and Technology, Chemistry, Department of Chemistry - Ångström. Uppsala University, Science for Life Laboratory, SciLifeLab.
Rudbeck Laboratory-Biomedical Radiation Sciences.
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(English)In: Biomaterials Science, ISSN 2047-4830Article in journal (Refereed) Submitted
Abstract [en]

An in situ cross-linkable hyaluronan hydrogel functionalized with bisphosphonate (BP) groups allows tunable release of bone morphogenetic protein-2 (BMP-2) determined by the amount of BP groups. Sequestration of BMP-2 in the hydrogel permits guided differentiation of entrapped progenitor cells in 3-D cultures. 

Place, publisher, year, edition, pages
Royal Society of Chemistry.
Keyword [en]
bisphosphonates, hydrogels, growth factors, tissue engineering, biomaterials
National Category
Polymer Chemistry
Research subject
Chemistry with specialization in Polymer Chemistry; Chemistry with specialization in Materials Chemistry
Identifiers
URN: urn:nbn:se:uu:diva-262530OAI: oai:DiVA.org:uu-262530DiVA: diva2:854169
Funder
EU, European Research Council, 262948-2EU, FP7, Seventh Framework Programme, 238551
Available from: 2015-09-16 Created: 2015-09-16 Last updated: 2015-09-16

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Kootala, SujitZhang, YuHilborn, JönsOssipov, Dmitri

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