uu.seUppsala University Publications
Change search
ReferencesLink to record
Permanent link

Direct link
Cognitive decline in patients with symptomtic HIV-1 infection: No decline in asymptomatic infection
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Oncology, Radiology and Clinical Immunology. (RAD)
Show others and affiliations
1996 (English)In: Acta Neurologica Scandinavica, ISSN 0001-6314, Vol. 93, no 6, 421-7 p.Article in journal (Refereed) Published
Abstract [en]

Thirty-six HIV-1-infected predominantly well-functioning subjects were followed up for one year by repeated neuropsychological, clinical neurological, neuroradiological, and immunological examinations. Changes in cognitive performance related to the severity of HIV-1 infection as well as to neuroradiological or immunological changes were studied. A decline in cognitive speed and flexibility was found in symptomatic subjects (ARC, AIDS). The impairment was especially pronounced in patients with progression of brain atrophy. These findings suggest a brain pathology underlying the cognitive decline in ambulatory outpatients with symptomatic HIV-1 infection. A practice effect was found in asymptomatic subjects (ASX, LAS) and in those with unchanged CT/MRI scans. No systematic relationship was found between cognitive change and immunological change.

Place, publisher, year, edition, pages
1996. Vol. 93, no 6, 421-7 p.
National Category
Medical and Health Sciences
URN: urn:nbn:se:uu:diva-57593PubMedID: 8836304OAI: oai:DiVA.org:uu-57593DiVA: diva2:85502
Available from: 2008-10-17 Created: 2008-10-17 Last updated: 2010-02-03Bibliographically approved

Open Access in DiVA

No full text

By organisation
Department of Oncology, Radiology and Clinical Immunology
In the same journal
Acta Neurologica Scandinavica
Medical and Health Sciences

Search outside of DiVA

GoogleGoogle Scholar
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

Altmetric score

Total: 157 hits
ReferencesLink to record
Permanent link

Direct link