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A prospective radiologic and neurologic follow-up study of 61 HIV-infected subjects: Early beginning and slow progression of brain atrophy
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Oncology, Radiology and Clinical Immunology. (RAD)
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1997 (English)In: European Journal of Neurology, ISSN 1351-5101, Vol. 4, no 2, 143-151 p.Article in journal (Refereed) Published
Abstract [en]

Abstract: The course of the organic brain disease caused by human immunodeficiency virus (HIV-1) was evaluated in a follow-up study. The primary material included 200 consecutive HIV-1 infected persons. Sixty-one subjects, in whom other brain-affecting factors were excluded, consented to the follow-up. They underwent 278 radiologic examinations: computed tomography, magnetic resonance imaging, or a combination of both (mean 4.6 examinations/subject). Clinical neurologic status and, in 40 subjects, cognitive performance were repeatedly evaluated. Sixteen subjects were followed up until death and 11 of them were autopsied. Median follow-up time was 27 mo (range 2.5-66 mo). The most common radiologic finding was atrophy, found in 19 subjects at study entry and developing in 10 subjects during the study. Twenty-four subjects (39%) showed the development and/or progression of atrophy. Atrophic changes progressed most rapidly in acquired immunodeficiency syndrome (AIDS), but mild developing/progressive atrophy was found even in 33% of asymptomatic or neurologically intact subjects. Cognitive and radiologic worsening were simultaneous in 6/7 subjects with declining neuropsychologic test performance. Signal intensity changes including HIV-1 leukoencephalopathy appeared in AIDS patients with clear cognitive decline.

Place, publisher, year, edition, pages
1997. Vol. 4, no 2, 143-151 p.
Keyword [en]
HIV-1 infection, MRT, CT, brain, atrophy, cognitive performance
National Category
Medical and Health Sciences
URN: urn:nbn:se:uu:diva-57596OAI: oai:DiVA.org:uu-57596DiVA: diva2:85505
Available from: 2008-10-17 Created: 2008-10-17 Last updated: 2010-02-04Bibliographically approved

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