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MRI of the brain in neurologically healthy middle-aged and elderly individuals
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Oncology, Radiology and Clinical Immunology. (RAD)
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1997 (English)In: Neuroradiology, ISSN 0028-3940, Vol. 39, no 8, 537-45 p.Article in journal (Refereed) Published
Abstract [en]

Our purpose was to document the MRI appearances of the brain in healthy middle-aged to elderly subjects. T2- and proton density-weighted axial slices were obtained in 61 volunteers, 30-86 years of age. After visual inspection, signal intensities of brain structures were measured on T2-weighted images. Age-related changes became increasingly apparent after age 50. The main findings were that signal intensity of the white matter increased concomitantly with widening of the cerebrospinal fluid spaces; that basal ganglia remained stable; that high-signal foci in white matter increased in number and size after the age of 50 years; that periventricular high-signal foci were constant after the age of 65 years. Our visual impression of a decrease in signal intensity of the central grey matter with age seems to be mistaken. Pathological processes should be suspected if periventricular foci are found in middle-aged or young subjects.

Place, publisher, year, edition, pages
1997. Vol. 39, no 8, 537-45 p.
Keyword [en]
Ageing brain, Magnetic resonance imaging, High-signal foci, Signal intensity
National Category
Medical and Health Sciences
URN: urn:nbn:se:uu:diva-57598DOI: 10.1007/s002340050463PubMedID: 9272488OAI: oai:DiVA.org:uu-57598DiVA: diva2:85507
Available from: 2008-10-17 Created: 2008-10-17 Last updated: 2010-02-04Bibliographically approved

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