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Preoperative quantitative MR tractography analysis compared with visual tract evaluation in patients with suspected low-grade gliomas.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Surgical Sciences, Radiology.
Bioimaging center, Lunds Universitet.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Neuroscience, Neurosurgery.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Surgical Sciences, Radiology.
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(English)Manuscript (preprint) (Other academic)
National Category
Medical and Health Sciences
Identifiers
URN: urn:nbn:se:uu:diva-262741OAI: oai:DiVA.org:uu-262741DiVA: diva2:855154
Available from: 2015-09-18 Created: 2015-09-18 Last updated: 2015-10-27
In thesis
1. Preoperative MRI and PET in suspected low-grade gliomas: Radiological, neuropathological and clinical intersections
Open this publication in new window or tab >>Preoperative MRI and PET in suspected low-grade gliomas: Radiological, neuropathological and clinical intersections
2015 (English)Doctoral thesis, comprehensive summary (Other academic)
Abstract [en]

Background: Gliomas are neuroepithelial tumours classified by cell type and grade. In adults, low-grade gliomas are comprised mainly of astrocytomas and oligodendrogliomas grade II. The aim was to non-invasively characterise suspected low-grade gliomas through use of 11C-methionine-PET and physiological MRI in order to facilitate treatment decisions.

Materials and methods: Patients with suspected low-grade glioma were prospectively and consecutively included after referral to the Neurosurgical Department, Uppsala University Hospital, between February 2010 and February 2014. All patients underwent morphological MRI, perfusion MRI, diffusion MRI and 11C-methionine PET. The institutional review board approved the study, and written informed consent was obtained prior to participation from each patient.

Results: 11C-methionine PET hot spot regions corresponded spatially with regions of maximum relative cerebral blood volume in dynamic susceptibility contrast (DSC) perfusion MRI. The skewness of the transfer constantin dynamic contrast-enhanced (DCE) perfusion MRI, and the standard deviation of relative cerebral blood flow in DSC perfusion MRI could most efficiently discriminate between glioma grades II and III. In diffusion MRI, tumour fractional anisotropy differed between suspected low-grade gliomas of different neuropathological types. Quantitative diffusion tensor tractography was applicable for the evaluation of tract segment infiltration.

Conclusion: PET and physiological MRI are able to characterise low-grade gliomas and are promising tools for guiding therapy and clinical decisions before neuropathological diagnosis has been obtained.

Place, publisher, year, edition, pages
Uppsala: Acta Universitatis Upsaliensis, 2015. 78 p.
Series
Digital Comprehensive Summaries of Uppsala Dissertations from the Faculty of Medicine, ISSN 1651-6206 ; 1136
Keyword
Low-grade glioma, MRI, PET, FA, MD, Perfusion, Diffusion, Neuropathology, Oligodendroglioma, Astrocytoma, PET, tractography, DTI, DTT
National Category
Radiology, Nuclear Medicine and Medical Imaging
Research subject
Radiology
Identifiers
urn:nbn:se:uu:diva-262742 (URN)978-91-554-9343-1 (ISBN)
Public defence
2015-11-06, Hedstrandsalen, Uppsala, 09:15 (Swedish)
Opponent
Supervisors
Available from: 2015-10-16 Created: 2015-09-18 Last updated: 2015-10-27Bibliographically approved

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