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Prophylactic antibiotics are associated with a lower incidence of pneumonia in cardiac arrest survivors treated with targeted temperature management
Maine Med Ctr, Dept Pharm, Portland, ME, USA.
Helsingborg Hosp, Dept Anesthesia & Intens Care, Helsingborg, Sweden.
Maine Med Ctr, Dept Pharm, Portland, ME 04102 USA.;Maine Med Ctr, Dept Crit Care Serv, Portland, ME 04102 USA..
Maine Med Ctr, Dept Crit Care Serv, Portland, ME 04102 USA.;Maine Med Ctr, Neurosci Inst, Portland, ME 04102 USA.;Maine Med Ctr, Div Pulm Med, Portland, ME 04102 USA..
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2015 (English)In: Resuscitation, ISSN 0300-9572, E-ISSN 1873-1570, Vol. 92, 154-159 p.Article in journal (Refereed) Published
Abstract [en]

Introduction: Prophylactic antibiotics (PRO) reduce the incidence of early-onset pneumonia in comatose patients with structural brain injury, but have not been examined in cardiac arrest survivors undergoing targeted temperature management (TTM). We investigated the effect of PRO on the development of pneumonia in that population. Methods: We conducted a retrospective cohort study comparing patients treated with PRO to those not receiving PRO (no-PRO) using Northern Hypothermia Network registry data. Cardiac arrest survivors >= 18 years of age with a GCS < 8 at hospital admission and treated with TTM at 32-34 degrees C were enrolled in the registry. Differences were analyzed in univariate analyses and with logistic regression models to evaluate independent associations of clinical factors with incidence of pneumonia and good functional outcome. Results: 416 of 1240 patients (33.5%) received PRO. Groups were similar in age, gender, arrest location, initial rhythm, and time from collapse to return of spontaneous circulation. PRO patients had less pneumonia (12.6% vs. 54.9%, p < 0.001) and less sepsis (1.2 vs. 5.7%, p < 0.001) compared to no-PRO patients. ICU length of stay (98 vs. 100 h, p = 0.2) and incidence of a good functional outcome (41.1 vs. 36.6%, p = 0.19) were similar between groups. Backwards stepwise logistic regression demonstrated PRO were independently associated with a lower incidence of pneumonia (OR 0.09, 95% 0.06-0.14, p < 0.001) and a similar incidence of good functional outcome. Conclusions: Prophylactic antibiotics were associated with a reduced incidence of pneumonia but a similar rate of good functional outcome.

Place, publisher, year, edition, pages
2015. Vol. 92, 154-159 p.
Keyword [en]
Cardiac arrest, Pneumonia, Hypothermia, Intensive care, Antibiotics, Temperature
National Category
Anesthesiology and Intensive Care
URN: urn:nbn:se:uu:diva-263046DOI: 10.1016/j.resuscitation.2015.01.035ISI: 000360352500038PubMedID: 25680823OAI: oai:DiVA.org:uu-263046DiVA: diva2:856886
Available from: 2015-09-25 Created: 2015-09-24 Last updated: 2015-09-25Bibliographically approved

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