uu.seUppsala University Publications
Change search
ReferencesLink to record
Permanent link

Direct link
Increase in the Prevalence of Atrophic Gastritis Among Adults Age 35 to 44 Years Old in Northern Sweden Between 1990 and 2009
Karolinska Inst, Dept Med Epidemiol & Biostat, SE-17177 Stockholm, Sweden..
Hallands Sjukhus Halmstad, Dept Clin Chem, Halmstad, Sweden..
Karolinska Inst, Dept Med Epidemiol & Biostat, SE-17177 Stockholm, Sweden..
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Clinical Microbiology and Infectious Medicine, Clinical Bacteriology.
Show others and affiliations
2015 (English)In: Clinical Gastroenterology and Hepatology, ISSN 1542-3565, Vol. 13, no 9, 1592-+ p.Article in journal (Refereed) Published
Abstract [en]

BACKGROUND & AIMS: Atrophic corpus gastritis (ACG) is believed to be an early precursor of gastric adenocarcinoma. We aimed to investigate trends of ACG in Northern Sweden, from 1990 through 2009, and to identify possible risk factors. METHODS: We randomly selected serum samples collected from 5284 participants in 1990, 1994, 1999, 2004, and 2009, as part of the population-based, cross-sectional Northern Sweden Multinational Monitoring of Trends and Determinants in Cardiovascular Disease study (ages, 35-64 y). Information was collected on sociodemographic, anthropometric, lifestyle, and medical factors using questionnaires. Serum samples were analyzed for levels of pepsinogen I to identify participants with functional ACG; data from participants with ACG were compared with those from frequency-matched individuals without ACG (controls). Blood samples were analyzed for antibodies against Helicobacter pylori and Cag pathogenicity island protein A. Associations were estimated with unconditional logistic regression models. RESULTS: Overall, 305 subjects tested positive for functional ACG, based on their level of pepsinogen I. The prevalence of ACG in participants age 55 to 64 years old decreased from 124 per 1000 to 49 per 1000 individuals between 1990 and 2009. However, the prevalence of ACG increased from 22 per 1000 to 64 per 1000 individuals among participants age 35 to 44 years old during this time period. Cag pathogenicity island protein A seropositivity was associated with risk for ACG (odds ratio, 2.29; 95% confidence interval, 1.69-3.12). Other risk factors included diabetes, low level of education, and high body mass index. The association between body mass index and ACG was confined to individuals age 35 to 44 years old; in this group, overweight and obesity were associated with a 2.8-fold and a 4.7-fold increased risk of ACG, respectively. CONCLUSIONS: Among residents of Northern Sweden, the prevalence of ACG increased from 1990 through 2009, specifically among adults age 35 to 44 years old. The stabilizing seroprevalence of H pylori and the increasing prevalence of overweight and obesity might contribute to this unexpected trend. Studies are needed to determine whether these changes have affected the incidence of gastric cancer.

Place, publisher, year, edition, pages
2015. Vol. 13, no 9, 1592-+ p.
Keyword [en]
MONICA Study, Secular Trend, BMI, Stomach
National Category
Gastroenterology and Hepatology
URN: urn:nbn:se:uu:diva-262957DOI: 10.1016/j.cgh.2015.04.001ISI: 000360090400012PubMedID: 25857683OAI: oai:DiVA.org:uu-262957DiVA: diva2:857635
Available from: 2015-09-29 Created: 2015-09-23 Last updated: 2015-09-29Bibliographically approved

Open Access in DiVA

No full text

Other links

Publisher's full textPubMed

Search in DiVA

By author/editor
Rautelin, Hilpi
By organisation
Clinical Bacteriology
In the same journal
Clinical Gastroenterology and Hepatology
Gastroenterology and Hepatology

Search outside of DiVA

GoogleGoogle Scholar
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

Altmetric score

Total: 158 hits
ReferencesLink to record
Permanent link

Direct link