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Oxidative injury and survival during endotoxemia
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Public Health and Caring Sciences. (Clinical Nutrition)
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Surgical Sciences. (Anaesthesiology and Intensive Care)
1998 (English)In: FEBS Letters, ISSN 0014-5793, E-ISSN 1873-3468, Vol. 438, no 3, 159-160 p.Article in journal (Refereed) Published
Abstract [en]

This study investigates the plasma levels of 8-iso-PGF2alpha, a non-enzymatic, and 15-K-DH-PGF2alpha, a cyclooxygenase catalyzed oxidation product of arachidonic acid in an experimental porcine endotoxemic shock model. A significant (P < 0.001) and rapid appearance and disappearance of PGF2alpha metabolite after endotoxin infusion was very similar in both non-survival and survival groups indicating an acute progression and recession of inflammation. When oxidative injury was assessed by measuring free 8-iso-PGF2alpha the levels in plasma increased significantly up to 2 h and remained at this level until death among the non-survivors. This was apparently different from the survivors where the 8-iso-PGF2alpha levels increased to its height at 1 h, then decreased to the basal levels after 5 h. Thus, free radical and cyclooxygenase catalyzed oxidation of arachidonic acid occurs during endotoxemia. Free radical dependent oxidative injury following endotoxin induced inflammation may be the major cause of organ failure and increased mortality.

Place, publisher, year, edition, pages
1998. Vol. 438, no 3, 159-160 p.
Keyword [en]
Inflammation, Oxidative stress, Endotoxin, Isoprostane, Prostaglandin, Septic shock
National Category
Medical and Health Sciences
Identifiers
URN: urn:nbn:se:uu:diva-57923DOI: 10.1016/S0014-5793(98)01290-3PubMedID: 9827537OAI: oai:DiVA.org:uu-57923DiVA: diva2:85832
Available from: 2008-10-17 Created: 2008-10-17 Last updated: 2017-12-01Bibliographically approved

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