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Prognostic significance of high hyperdiploid and triploid/tetraploid adult acute myeloid leukemia
Skane Univ Hosp, Dept Hematol & Vasc Dis, SE-22185 Lund, Sweden.;Lund Univ, Stem Cell Ctr, Lund, Sweden..
Skane Univ Hosp, Epidemiol & Registry Ctr South Sweden, SE-22185 Lund, Sweden..
Skane Univ Hosp, Dept Hematol & Vasc Dis, SE-22185 Lund, Sweden.;Lund Univ, Stem Cell Ctr, Lund, Sweden..
Linkoping Univ Hosp, Dept Hematol, S-58185 Linkoping, Sweden..
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2015 (English)In: American Journal of Hematology, ISSN 0361-8609, E-ISSN 1096-8652, Vol. 90, no 9, 800-805 p.Article in journal (Refereed) Published
Abstract [en]

To ascertain the clinical implications of high hyperdiploid (HH; 49-65 chromosomes) and triploid/tetraploid (TT; >65 chromosomes) adult acute myeloid leukemia (AML), all such cases were retrieved from the Swedish AML Registry. Of the 3,654 cytogenetically informative cases diagnosed between January 1997 and May 2014, 68 (1.9%) were HH (n=50)/TT (n=18). Patients with HH/TT were older than those with intermediate risk (IR) AML (median 71 years vs. 67 years; P=0.042) and less often had de novo AML (63% vs. 79%; P=0.004); no such differences were observed between HH/TT and complex karyotype (CK) AML. The overall survival (OS) was similar between patients with HH/TT and CK AML (median 0.9 years vs. 0.6 years; P=0.082), whereas OS was significantly longer (median 1.6 years; P=0.028) for IR AML. The OS was shorter for cases with HH than with TT (median 0.6 years vs. 1.4 years; P=0.032) and for HH/TT AMLs with adverse abnormalities (median 0.8 years vs. 1.1 years; P=0.044). In conclusion, HH/TT AML is associated with a poor outcome, but chromosome numbers >65 and absence of adverse aberrations seem to translate into a more favorable prognosis. Thus, HH/TT AMLs are clinically heterogeneous and should not automatically be grouped as high risk.Am. J. Hematol. 90:800-805, 2015.

Place, publisher, year, edition, pages
2015. Vol. 90, no 9, 800-805 p.
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URN: urn:nbn:se:uu:diva-262951DOI: 10.1002/ajh.24091ISI: 000360218000023PubMedID: 26088289OAI: oai:DiVA.org:uu-262951DiVA: diva2:858401
Swedish Cancer SocietySwedish Research CouncilSwedish Association of Local Authorities and Regions
Available from: 2015-10-02 Created: 2015-09-23 Last updated: 2015-12-29Bibliographically approved

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