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Risk of disability pension in patients following rectal cancer treatment and surgery
Karolinska Inst, Dept Med Solna, Clin Epidemiol Unit, Stockholm, Sweden..
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Immunology, Genetics and Pathology, Experimental and Clinical Oncology. Karolinska Inst, Dept Med Solna, Clin Epidemiol Unit, Stockholm, Sweden..
Karolinska Inst, Dept Med Solna, Clin Epidemiol Unit, Stockholm, Sweden..
Karolinska Inst, Dept Med Solna, Clin Epidemiol Unit, Stockholm, Sweden..
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2015 (English)In: British Journal of Surgery, ISSN 0007-1323, E-ISSN 1365-2168, Vol. 102, no 11, 1426-1432 p.Article in journal (Refereed) Published
Abstract [en]

BackgroundAspects of survivorship, such as long-term ability to work, are increasingly relevant owing to the improved survival of patients with rectal cancer. The aim of this study was to assess risk and determinants of disability pension (DP) in this patient group. MethodsUsing Swedish national clinical and population-based registers, patients with stage I-III rectal cancer aged 18-61years in 1995-2009 were identified at diagnosis and matched with population comparators. Prospectively registered records of DP during follow-up were retrieved up to 2013. Non-proportional and proportional hazards models were used to estimate the incidence rate ratio (IRR) for DP annually and overall. Potential variations in risk by demographic and clinical factors were calculated, with relapse as a time-varying exposure. ResultsA total of 2815 patients were identified and compared with 13465 population comparators. During a median follow-up of 60 (range 0-10) years, 233 per cent of the relapse-free patients and 103 per cent of the population comparators received DP (IRR 240, 95 per cent c.i. 217 to 265). An increased annual risk of DP was evident almost every year until the tenth year of follow-up. Abdominoperineal resection was associated with an increased DP risk compared with anterior resection (IRR 144, 119 to 175). Surgical complications (IRR 133, 110 to 162) and reoperation (IRR 142, 109 to 184), but not radiotherapy or chemotherapy, were associated with risk of DP. ConclusionRelapse-free patients with rectal cancer of working age are at risk of disability pension. Higher than expected

Place, publisher, year, edition, pages
2015. Vol. 102, no 11, 1426-1432 p.
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Cancer and Oncology Surgery
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URN: urn:nbn:se:uu:diva-264026DOI: 10.1002/bjs.9885ISI: 000361228000017PubMedID: 26215637OAI: oai:DiVA.org:uu-264026DiVA: diva2:859423
Available from: 2015-10-07 Created: 2015-10-05 Last updated: 2017-12-01Bibliographically approved

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