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Pregnancy and perinatal outcomes in women with polycystic ovary syndrome and twin births: a population-based cohort study
Norwegian Univ Sci & Technol, Inst Lab Med Childrens & Womens Hlth, N-7034 Trondheim, Norway.;St Olavs Hosp, Dept Obstet & Gynaecol, N-7006 Trondheim, Norway..
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Women's and Children's Health, Obstetrics and Gynaecology. Karolinska Inst, Clin Epidemiol Unit, Dept Med, Stockholm, Sweden..
Karolinska Inst, Clin Epidemiol Unit, Dept Med, Stockholm, Sweden..
Karolinska Inst, Clin Epidemiol Unit, Dept Med, Stockholm, Sweden.;Karolinska Inst, Div Obstet & Gynaecol, Dept Womens & Childrens Hlth, Stockholm, Sweden..
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2015 (English)In: British Journal of Obstetrics and Gynecology, ISSN 1470-0328, E-ISSN 1471-0528, Vol. 122, no 10, 1295-1302 p.Article in journal (Refereed) Published
Abstract [en]

Objective:To investigate pregnancy and perinatal outcomes in twin births among women with and without polycystic ovary syndrome (PCOS) diagnosis. Design: Population-based cohort study. Setting: Sweden. Population: We identified 20965 women with twin births between 1995 and 2009 of whom 226 had a PCOS diagnosis through linkage between the Swedish Medical Birth Register and the Swedish National Patient Register. Methods: Calculating risk ratios (RR) with 95% confidence intervals (CI) using a log-binomial regression model and hazard ratios (HR) with 95% CI for preterm birth. Main outcome measures: Preterm birth, low birthweight, caesarean section, pre-eclampsia, Apgar score <7 at 5minutes and perinatal mortality. Results: PCOS diagnosis in twin pregnancy was associated with increased risk of preterm delivery (51% versus 43%, RR 1.18 [95% CI 1.03-1.37]), particularly spontaneous preterm delivery (37% versus 28%; RR 1.30 [95% CI 1.09-1.55]) and very preterm birth (<32weeks) (14% versus 8%, RR 1.62 [95% CI 1.10-2.37]). Twins of PCOS mothers had more often low birthweight (48% versus 39%, adjusted RR 1.40 [95% CI 1.09-1.80]). This difference disappeared when adjusting for gestational age. No risk difference was found for caesarean section, pre-eclampsia, low 5-minute Apgar score or perinatal mortality. Conclusions: The risk of preterm delivery in twin pregnancies is increased by having a PCOS diagnosis. This should be considered in risk estimation and antenatal follow-up of twin pregnancies.

Place, publisher, year, edition, pages
2015. Vol. 122, no 10, 1295-1302 p.
Keyword [en]
Cohort study, polycystic ovary syndrome, pregnancy outcome, preterm birth, twins
National Category
Obstetrics, Gynecology and Reproductive Medicine
URN: urn:nbn:se:uu:diva-263439DOI: 10.1111/1471-0528.13339ISI: 000360374600003PubMedID: 25761516OAI: oai:DiVA.org:uu-263439DiVA: diva2:859466
Available from: 2015-10-07 Created: 2015-09-30 Last updated: 2015-10-07Bibliographically approved

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Wikström, Anna-Karin
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