Bronchoconstriction induced by inhaled methacholine delays desflurane uptake and elimination in a piglet model
2016 (English)In: Respiratory Physiology & Neurobiology, ISSN 1569-9048, E-ISSN 1878-1519, Vol. 220, 88-94 p.Article in journal (Refereed) Published
Bronchoconstriction is a hallmark of asthma and impairs gas exchange. We hypothesized that pharmacokinetics of volatile anesthetics would be affected by bronchoconstriction. Ventilation/perfusion (V̇A/Q̇) ratios and pharmacokinetics of desflurane in both healthy state and during inhalational administration of methacholine (MCh) to double peak airway pressure were studied in a piglet model. In piglets, MCh administration by inhalation (100μg/ml, n=6) increased respiratory resistance, impaired V̇A/Q̇ distribution, increased shunt, and decreased paO2 in all animals. The uptake and elimination of desflurane in arterial blood was delayed by nebulization of MCh, as determined by Micropore Membrane Inlet Mass Spectrometry (wash-in time to P50, healthy vs. inhalation: 0.5min vs. 1.1min, to P90: 4.0min vs. 14.8min). Volatile elimination was accordingly delayed. Inhaled methacholine induced severe bronchoconstriction and marked inhomogeneous V̇A/Q̇ distribution in pigs, which is similar to findings in human asthma exacerbation. Furthermore, MCh-induced bronchoconstriction delayed both uptake and elimination of desflurane. These findings might be considered when administering inhalational anesthesia to asthmatic patients.
Place, publisher, year, edition, pages
2016. Vol. 220, 88-94 p.
Physiology Respiratory Medicine and Allergy
Research subject Physiology
IdentifiersURN: urn:nbn:se:uu:diva-264207DOI: 10.1016/j.resp.2015.09.014ISI: 000368045500012PubMedID: 26440992OAI: oai:DiVA.org:uu-264207DiVA: diva2:859519
FunderSwedish Research Council, 5315 X2015-99x-22731-01-04Swedish Heart Lung Foundation