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Acoustophoretic removal of proteins from blood components
Uppsala University, Disciplinary Domain of Science and Technology, Technology, Department of Engineering Sciences, Microsystems Technology. Uppsala University, Science for Life Laboratory, SciLifeLab. (EMBLA)ORCID iD: 0000-0002-1264-1337
Skane Univ Hosp, Dept Clin Immunol & Transfus Med, Lund, Sweden.
Skane Univ Hosp, Dept Clin Immunol & Transfus Med, Lund, Sweden.
Skane Univ Hosp, Dept Clin Immunol & Transfus Med, Lund, Sweden.
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2015 (English)In: Biomedical microdevices (Print), ISSN 1387-2176, E-ISSN 1572-8781, Vol. 17, no 5, UNSP 95Article in journal (Refereed) Published
Abstract [en]

This work presents the development of a miniaturized system for removing plasma proteins and other low-molecular-weight compounds from red blood cell (RBC) concentrate in a simple one-step-process using integrated ultrasound. The technology utilizes the principles of acoustophoresis to transfer the RBCs from the original plasma-containing solution into a protein-free SAG-M additive solution in a continuous flow process. The preparation of protein free RBC concentrate is important for blood transfusion to patients suffering from immunoglobulin A (IgA)-deficiency and developing antibodies against IgA. We show a nearly complete removal of both albumin and IgA from concentrated RBCs via this one-step-processes in samples obtained from RBC concentrate. The cell recovery of our technology is close to 97 %, compared to just above 90 % of the current procedure of repeated dilution and centrifugation steps. This work clearly shows the potential of integrated acoustophoresis in a miniaturized system for clinical applications.

Place, publisher, year, edition, pages
2015. Vol. 17, no 5, UNSP 95
Keyword [en]
Acoustophoresis; Blood component preparation; IgA deficiency
National Category
Engineering and Technology
Research subject
Engineering Science with specialization in Microsystems Technology
Identifiers
URN: urn:nbn:se:uu:diva-264305DOI: 10.1007/s10544-015-0003-5ISI: 000362281200012PubMedID: 26315975OAI: oai:DiVA.org:uu-264305DiVA: diva2:859924
Funder
VINNOVA, 2009-00236Swedish Research Council for Environment, Agricultural Sciences and Spatial Planning, 221-2011-1692
Available from: 2015-10-09 Created: 2015-10-09 Last updated: 2017-12-01Bibliographically approved

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Tenje, Maria

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