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Graft function 1 year after pregnancy in an islet-transplanted patient
Oslo Univ Hosp, Dept Transplant Med, N-0424 Oslo, Norway.;Oslo Univ Hosp, Inst Surg Res, N-0424 Oslo, Norway.;Univ Oslo, Inst Clin Med, Oslo, Norway..
Oslo Univ Hosp, Dept Transplant Med, N-0424 Oslo, Norway.;Oslo Univ Hosp, Inst Surg Res, N-0424 Oslo, Norway.;Univ Oslo, Inst Clin Med, Oslo, Norway..
Oslo Univ Hosp, Dept Transplant Med, N-0424 Oslo, Norway.;Oslo Univ Hosp, Inst Surg Res, N-0424 Oslo, Norway.;Univ Oslo, Inst Clin Med, Oslo, Norway..
Oslo Univ Hosp, Dept Transplant Med, N-0424 Oslo, Norway.;Oslo Univ Hosp, Inst Surg Res, N-0424 Oslo, Norway.;Univ Oslo, Inst Clin Med, Oslo, Norway..
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2015 (English)In: Transplant International, ISSN 0934-0874, E-ISSN 1432-2277, Vol. 28, no 10, 1235-1239 p.Article in journal (Refereed) Published
Abstract [en]

Pancreatic islet transplantation is a treatment option for patients with type 1 diabetes (T1D), but pregnancy has generally not been advised for women after receiving an islet allograft. We hereby describe what is to our knowledge the first successful pregnancy and persistent graft function in a woman 4years after her initial islet transplantation. A 37-year-old woman with brittle type 1 diabetes was transplanted with two separate islet graft infusions, eventually becoming insulin independent. Ten months after her second transplantation, her immunosuppression was switched from tacrolimus and sirolimus to tacrolimus, azathioprine, and prednisolone, due to her wish to become pregnant. She became pregnant one year later, and after 38weeks of uncomplicated pregnancy, she gave birth to a healthy child by C-section. The current report suggests that pregnancy and childbirth can be accomplished after islet transplantation without loss of islet graft function.

Place, publisher, year, edition, pages
2015. Vol. 28, no 10, 1235-1239 p.
Keyword [en]
glucocorticoids, islet transplantation, pregnancy, type 1 diabetes
National Category
Endocrinology and Diabetes Immunology in the medical area
Identifiers
URN: urn:nbn:se:uu:diva-263427DOI: 10.1111/tri.12596ISI: 000360758500015PubMedID: 25903157OAI: oai:DiVA.org:uu-263427DiVA: diva2:860313
Available from: 2015-10-12 Created: 2015-09-30 Last updated: 2018-01-11Bibliographically approved

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Korsgren, Olle

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