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The effect of gentamicin on cytoskeletons in the vestibular sensory cells:a high-resolution scanning electron microscopic investigation
(Ear-Nose-Throat)
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Surgical Sciences. (Ear-Nose-Throat)
1996 (English)In: Acta Oto-Laryngologica, ISSN 0001-6489, E-ISSN 1651-2251, Vol. 116, no 6, 817-23 p.Article in journal (Refereed) Published
Abstract [en]

The effect of gentamicin on the cytoskeletal organization of guniea pig vestibular sensory cells was investigated employing the saponin perfusion method and scanning electron microscopy. The intermediate filaments and microtubules were noted to have degenerated following gentamicin intoxication. Such degeneration was not linked with primary mitochondrial damage, but closely related to subsequent degeneration of Golgi apparatus and of endoplasmic reticulum. These findings suggest that microtubules and intermediate filaments work closely together to maintain the structural integrity of both the Golgi apparatus and the membrane-bound organelles, which can be altered by ototoxic drugs before the degeneration of membrane-bound organelles.

Place, publisher, year, edition, pages
1996. Vol. 116, no 6, 817-23 p.
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Medical and Health Sciences
Identifiers
URN: urn:nbn:se:uu:diva-58158PubMedID: 8973713OAI: oai:DiVA.org:uu-58158DiVA: diva2:86067
Available from: 2008-10-17 Created: 2008-10-17 Last updated: 2017-12-01Bibliographically approved

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