Auditory epithelial migration: II: Morphological evidence for auditory epidermal cell migration in rat
1996 (English)In: Acta Oto-Laryngologica, ISSN 0001-6489, Vol. 116, no 6, 850-3 p.Article in journal (Refereed) Published
Morphology of the tympanic membrane (TM) and external auditory canal (EAC) was studied in healthy, intact rat ears. TM-perforated ears (3 days after making the perforation) and TM-perforation-healed ears (14, 28 and 42 days after making the perforation). In intact ears, the epidermis in the annular region of the EAC displayed a characteristic appearance with cytoplasmic protrusions. We termed these protrusions as "finger-like projections". In contrast to the rat, the annular region of the EAC in the guinea-pig did not show "finger-like projections". Following a perforation in the centre of the anterior or the posterior quadrant of the pars tensa in rats the "finger-like projections" disappeared from the annular region on the perforated side of the EAC, while the projections remained on the malleus side of the perforation edge. In perforation-healed ears analysed 42 days after the perforation, the "finger-like projections" had recurred in the annular region on the perforated side of the EAC. The "finger-like projections" are likely to express maturation (keratinization) and desquamation of epidermal cells in the pars tensa and also could constitute morphological evidence of their migration on the TM.
Place, publisher, year, edition, pages
1996. Vol. 116, no 6, 850-3 p.
Medical and Health Sciences
IdentifiersURN: urn:nbn:se:uu:diva-58161PubMedID: 8973720OAI: oai:DiVA.org:uu-58161DiVA: diva2:86070