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Programmed cell death in the mouse cochleovestibular ganglion during development
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Surgical Sciences. (Oto-Rhino-Laryngology, Head & Neck Surgery)
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1998 (English)In: Journal for Oto-Rhino-Laryngology, ISSN 0301-1569, Vol. 60, no 5, 267-71 p.Article in journal (Refereed) Published
Abstract [en]

Programmed cell death (PCD) is as essential to development as is cell proliferation. Our objective was to elucidate the spatiotemporal occurrence of PCD during the development of the cochleovestibular ganglion. We performed a time-sequence study on the distribution of in situ PCD, apoptosis, during the development of the mouse cochleovestibular ganglion by using the TUNEL method to detect apoptosis histochemically. Apoptosis in the cochleovestibular ganglion was observed from the 11.5th gestational day (GD) to the 18. 5th GD. Apoptosis was seen most extensively in the vestibular ganglion cells at the 13.5th GD, while in the spiral ganglion cells apoptosis was maximal between the 15.5th and 16.5th GD. Because these times of peak apoptotic activity almost exactly corresponded to the events of innervation and terminal mitosis of the cochleovestibular ganglion cells, we infer that PCD is involved in the innervation and modulates the number of cochleovestibular ganglion cells overproduced by terminal mitosis.

Place, publisher, year, edition, pages
1998. Vol. 60, no 5, 267-71 p.
Keyword [en]
Apoptosis, Programmed cell death, Cochleovestibular ganglion, Development, Mouse
National Category
Medical and Health Sciences
URN: urn:nbn:se:uu:diva-58176DOI: 10.1159/000027608PubMedID: 9693303OAI: oai:DiVA.org:uu-58176DiVA: diva2:86085
Available from: 2008-10-17 Created: 2008-10-17 Last updated: 2010-03-03Bibliographically approved

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