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Virus removal paper filter made of 100% naturally derived nanofibers
Uppsala University, Disciplinary Domain of Science and Technology, Technology, Department of Engineering Sciences, Nanotechnology and Functional Materials.
Uppsala University, Disciplinary Domain of Science and Technology, Technology, Department of Engineering Sciences, Nanotechnology and Functional Materials.
Charles River Biopharmaceutical Services Gmbh.
Charles River Biopharmaceutical Services Gmbh.
2015 (English)Conference paper, Poster (with or without abstract) (Refereed)
Abstract [en]

AIM AND METHODOLOGY: The aim of this study was to validate the virus removal properties of nanocellulose based filter paper. The filter paper was characterized with atomic force microscopy (AFM), nitrogen gas adsorption and scanning electron microscopy (SEM).Polystyrene latex beads (100nm), gold nanoparticles (50 nm), and murine leukemia virus (MuLV) spiked solutions were used as models.

AFM IMAGE: The filter paper consists of 20-­‐30 nm cellulose nanofibers bundles which form an open 3D porous structure.

GAS ADSORPTION: Most of the pores are 20 nm in size, and no pores larger than 40 nm could be detected.

VISUAL OBSERVATION: A precipitate was clearly seen following the filtration of gold nanoparticles, and the originally red solution of gold nanoparticles turned completely colorless.

SEM: Polystyrne latex beads (100 nm)and gold nanoparticles (50 nm) were efficiently retained on the nanocellulose based filter paper.

MuLV RETENTION TEST: LRV ≥ 5 was observed after filtration as limited by the virus titre in the feed solution and the lower detection limit of TCID50 method.

CONCLUSION: Nanocellulose based filter paper is highly promising for developing a new line of virus removal filters for biotechnological applications, comparable to the state of the art membrane materials.

Place, publisher, year, edition, pages
2015.
National Category
Nano Technology
Identifiers
URN: urn:nbn:se:uu:diva-264534OAI: oai:DiVA.org:uu-264534DiVA: diva2:860851
Conference
Parenteral Drug Association (PDA) Annual Meeting 2015, Mar 16-17, 2015 Las Vegas, USA
Available from: 2015-10-14 Created: 2015-10-14 Last updated: 2015-10-15Bibliographically approved

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Mihranyan, Albert

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