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Bisphosphonate-modified biomaterials for drug delivery and bone tissue engineering
Uppsala University, Disciplinary Domain of Science and Technology, Chemistry, Department of Chemistry - Ångström, Polymer Chemistry. Uppsala University, Science for Life Laboratory, SciLifeLab.
2015 (English)In: Expert Opinion on Drug Delivery, ISSN 1742-5247, E-ISSN 1744-7593, Vol. 12, no 9, 1443-1458 p.Article, review/survey (Refereed) Published
Abstract [en]

Introduction: Bisphosphonates (BPs) were introduced 45 years ago as anti-osteoporotic drugs and during the last decade have been utilized as bone-targeting groups in systemic treatment of bone diseases. Very recently, strategies of chemical immobilization of BPs in hydrogels and nanocomposites for bone tissue engineering emerged. These strategies opened new applications of BPs in bone tissue engineering. Areas covered: Conjugates of BPs to different drug molecules, imaging agents, proteins and polymers are discussed in terms of specific targeting to bone and therapeutic affect induced by the resulting prodrugs in comparison with the parent drugs. Conversion of these conjugates into hydrogel scaffolds is also presented along with the application of the resulting materials for bone tissue engineering. Expert opinion: Calcium-binding properties of BPs can be successfully extended via different conjugation strategies not only for purposes of bone targeting, but also in supramolecular assembly affording either new nanocarriers or bulk nanoconnposite scaffolds. Interaction between carrier-linked BPs and drug molecules should also be considered for the control of release of these molecules and their optimized delivery. Bone-targeting properties of BP-functionalized nanomaterials should correspond to bone adhesive properties of their bulk analogs.

Place, publisher, year, edition, pages
Uppsala Univ, Sci Life Lab, Div Polymer Chem, Dept Chem Angstrom, SE-75121 Uppsala, Sweden., 2015. Vol. 12, no 9, 1443-1458 p.
Keyword [en]
bisphosphonates, bone cancer, bone regeneration, growth factor delivery, hydrogels nanoparticles, osteoporosis
National Category
Pharmacology and Toxicology Cancer and Oncology
Identifiers
URN: urn:nbn:se:uu:diva-264486DOI: 10.1517/17425247.2015.1021679ISI: 000360184400005PubMedID: 25739860OAI: oai:DiVA.org:uu-264486DiVA: diva2:860889
Available from: 2015-10-14 Created: 2015-10-13 Last updated: 2017-12-01Bibliographically approved

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Ossipov, Dmitri A.

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