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The Vitality, Independence, and Vigor in the Elderly 2 Study (VIVE2): Design and methods
Tufts Univ, Nutr Exercise Physiol & Sarcopenia Lab, Jean Mayer USDA Human Nutr Res Ctr Aging, Boston, MA 02111 USA..
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Public Health and Caring Sciences, Clinical Nutrition and Metabolism.
Tufts Univ, Nutr Exercise Physiol & Sarcopenia Lab, Jean Mayer USDA Human Nutr Res Ctr Aging, Boston, MA 02111 USA..
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Public Health and Caring Sciences, Clinical Nutrition and Metabolism.
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2015 (English)In: Contemporary Clinical Trials, ISSN 1551-7144, E-ISSN 1559-2030, Vol. 43, 164-171 p.Article in journal (Refereed) Published
Abstract [en]

Background: Nutritional supplementation may potentiate the increase in skeletal muscle protein synthesis following exercise in healthy older individuals. Whether exercise and nutrition act synergistically to produce sustained changes in physical functioning and body composition has not been well studied, particularly in mobility-limited older adults. Methods: The VIVE2 study was a multi-center, randomized controlled trial, conducted in the United States and Sweden. This study was designed to compare the effects of a 6-month intervention with a once daily, experimental, 4 fl. oz. liquid nutritional supplement providing 150 kcal, whey protein (20 g), and vitamin D (800 IU) (Nestle Health Science, Vevey, Switzerland), to a low calorie placebo drink (30 kcal, non-nutritive; identical format) when combined with group-based exercise in 150 community-dwelling, mobility-limited older adults. All participants participated in a structured exercise program (3 sessions/week for 6 months), which included aerobic, strength, flexibility, and balance exercises. Results: The primary outcome was 6-month change in 400 m walk performance (m/s) between supplement and placebo groups. Secondary outcomes included 6 month change in: body composition, muscle cross-sectional area, leg strength, grip strength, stair climb time, quality of life, physical performance, mood/depressive symptoms and nutritional status. These outcomes were selected based on their applicability to the health and wellbeing of older adults. Conclusions: The results of this study will further define the role of nutritional supplementation on physical functioning and restoration of skeletal muscle mass in older adults. Additionally, these results will help refine the current physical activity and nutritional recommendations for mobility-limited older adults.

Place, publisher, year, edition, pages
2015. Vol. 43, 164-171 p.
Keyword [en]
Older adults, Mobility-limitations, Physical activity, Protein, Vitamin D, Supplementation
National Category
Geriatrics Nutrition and Dietetics
Identifiers
URN: urn:nbn:se:uu:diva-264329DOI: 10.1016/j.cct.2015.06.001ISI: 000360773200021PubMedID: 26044464OAI: oai:DiVA.org:uu-264329DiVA: diva2:861048
Available from: 2015-10-15 Created: 2015-10-09 Last updated: 2017-12-01

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Koochek, Afsanehvon Berens, AsaÅberg, Anna CristinaCederholm, Tommy

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Clinical Nutrition and MetabolismDepartment of Food, Nutrition and DieteticsGeriatrics
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Contemporary Clinical Trials
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