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Resorbable Bioscaffold for Esophageal Repair in a Dog Model
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Surgical Sciences. (Paediatric Surgery)
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2000 (English)In: Journal of Pediatric Surgery, ISSN 0022-3468, E-ISSN 1531-5037, Vol. 35, no 7, 1097-1103 p.Article in journal (Refereed) Published
Abstract [en]

Purpose: Porcine-derived, xenogeneic extracellular matrix (ECM) derived from either the small intestinal submucosa (SIS) or urinary bladder submucosa (UBS) was used as a tissue scaffold for esophageal repair in a dog model. Methods: Patch defects measuring approximately 5 cm in length and encompassing 40% to 50% of the circumference of the esophagus or complete circumferential segmental defects measuring 5 cm in length were created by surgical resection in healthy adult female dogs. The defects were repaired with ECM scaffolds derived from either SIS or UBS. The animals were kept alive for periods ranging from 4 days to 15 months. Results: The xenogeneic scaffolds used for repair of the patch defects were resorbed completely within 30 to 60 days and showed replacement by skeletal muscle, which was oriented appropriately and contiguous with adjacent normal esophageal skeletal muscle, organized collagenous connective tissue, and a complete and intact squamous epithelium. No signs of clinical esophageal dysfunction were seen in any of the animals with the patch defect repair. The xenogeneic scaffolds configured into tubes for repair of the segmental defects all showed stricture within 45 days of surgery. Conclusion: These ECMs show promise as a treatment option for esophageal repair, but stricture remains problematic for complete tube grafts.

Place, publisher, year, edition, pages
2000. Vol. 35, no 7, 1097-1103 p.
National Category
Medical and Health Sciences
URN: urn:nbn:se:uu:diva-58313DOI: 10.1053/jpsu.2000.7834OAI: oai:DiVA.org:uu-58313DiVA: diva2:86222
Available from: 2008-10-17 Created: 2008-10-17 Last updated: 2014-07-11Bibliographically approved

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