Longitudinal relationship between inflammation and poor self-rated health in elderly
2015 (English)In: Brain, behavior, and immunity, ISSN 0889-1591, E-ISSN 1090-2139, Vol. 49S, e37Article in journal, Meeting abstract (Refereed) Published
Self-rated health (SRH) predicts future objective health and summarizes information in a way that goes beyond the biomedical health model. Low-grade inflammation contributes to poor SRH, but previous findings rely on cross-sectional analyses. We therefore studied the relationship between SRH and IL-6 in a longitudinal study of elderly. Participants (m = 74 years; range 60–93; 41% male) were studied in 6-month waves over a period up to 5 years. SRH was measured with a one-item question (excellent to poor). Serum was collected following the interview visit (median interval 40 days), frozen at −80 °C and later analyzed with high-sensitivity ELISA for IL-6. Overall, 999 observations were available for analysis. When analyzed as a between-subject effect, a stable relationship was observed between SRH and logIL-6 (β = −.088; p < .001). However, the within-subject effect of SRH on IL-6 was not significant. The effects were not explained by gender, age, BMI, neuroticism, or statin use. There was no main effect of interview-to-blood sample interval, neither between nor within subjects. Putative variations over time in the relation between SRH and IL-6 could thus not be captured with the present design. With the advantage of a longitudinal design and multiple sampling occasions, the present data strongly support the stability of the previously reported cross-sectional relationship between higher levels of inflammatory cytokines and less favorable health appraisals across individuals.
Place, publisher, year, edition, pages
2015. Vol. 49S, e37
IdentifiersURN: urn:nbn:se:uu:diva-265163DOI: 10.1016/j.bbi.2015.06.142OAI: oai:DiVA.org:uu-265163DiVA: diva2:862687
PsychoNeuroImmunology Research Society's 22nd Annual Scientific Meeting
PsychoNeuroImmunology Research Society's 22nd Annual Scientific Meeting2015-10-232015-10-232015-10-23Bibliographically approved