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Longitudinal relationship between inflammation and poor self-rated health in elderly
Stress Research Institute, Stockholm University; Osher Center for Integrative Medicine, Karolinska Institutet.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Medicinska och farmaceutiska vetenskapsområdet, centrumbildningar mm, National Center for Disaster Psychiatry. Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Neuroscience, Psychiatry, University Hospital. Stress Research Institute, Stockholm University.ORCID iD: 0000-0002-1317-2093
Department of Psychology, University of Kentucky.
2015 (English)In: Brain, behavior, and immunity, ISSN 0889-1591, E-ISSN 1090-2139, Vol. 49S, e37Article in journal, Meeting abstract (Refereed) Published
Abstract [en]

Self-rated health (SRH) predicts future objective health and summarizes information in a way that goes beyond the biomedical health model. Low-grade inflammation contributes to poor SRH, but previous findings rely on cross-sectional analyses. We therefore studied the relationship between SRH and IL-6 in a longitudinal study of elderly. Participants (m = 74 years; range 60–93; 41% male) were studied in 6-month waves over a period up to 5 years. SRH was measured with a one-item question (excellent to poor). Serum was collected following the interview visit (median interval 40 days), frozen at −80 °C and later analyzed with high-sensitivity ELISA for IL-6. Overall, 999 observations were available for analysis. When analyzed as a between-subject effect, a stable relationship was observed between SRH and logIL-6 (β = −.088; p < .001). However, the within-subject effect of SRH on IL-6 was not significant. The effects were not explained by gender, age, BMI, neuroticism, or statin use. There was no main effect of interview-to-blood sample interval, neither between nor within subjects. Putative variations over time in the relation between SRH and IL-6 could thus not be captured with the present design. With the advantage of a longitudinal design and multiple sampling occasions, the present data strongly support the stability of the previously reported cross-sectional relationship between higher levels of inflammatory cytokines and less favorable health appraisals across individuals.

Place, publisher, year, edition, pages
2015. Vol. 49S, e37
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URN: urn:nbn:se:uu:diva-265163DOI: 10.1016/j.bbi.2015.06.142OAI: oai:DiVA.org:uu-265163DiVA: diva2:862687
PsychoNeuroImmunology Research Society's 22nd Annual Scientific Meeting

PsychoNeuroImmunology Research Society's 22nd Annual Scientific Meeting

Available from: 2015-10-23 Created: 2015-10-23 Last updated: 2015-10-23Bibliographically approved

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Arnberg, Filip K
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National Center for Disaster PsychiatryPsychiatry, University Hospital
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